Proteins/UNIPROT:Q8N8N0

RNF152

ProteinUNIPROT:Q8N8N0

E3 ubiquitin-protein ligase that acts as a negative regulator of mTORC1 signaling by mediating ubiquitination of RagA/RRAGA and RHEB. Catalyzes 'Lys-63'-linked polyubiquitination of RagA/RRAGA in response to amino acid starvation, thereby regulating mTORC1 signaling. Also mediates monoubiquitination of RHEB, promoting its association with the TSC-TBC complex and subsequent inhibition. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed..

Function from UniProtKB (Q8N8N0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

14 statements

14 statements · 3 reference databases · Subject: RNF152 · Sources: gene ontology, Hetionet, Reactome

Order

RNF152 covaries with ADGRG5ProteinHetionet hetionet:covaries:220441-221188Inferred only
THOP1 covaries with RNF152ProteinHetionet hetionet:covaries:220441-7064Inferred only
TMEM238 covaries with RNF152ProteinHetionet hetionet:covaries:220441-388564Inferred only
UBE2G2 covaries with RNF152ProteinHetionet hetionet:covaries:220441-7327Inferred only
UBL5 covaries with RNF152ProteinHetionet hetionet:covaries:220441-59286Inferred only
CROCC interacts with RNF152ProteinHetionet hetionet:interacts:220441-9696Inferred only
UBE2E1 interacts with RNF152ProteinHetionet hetionet:interacts:220441-7324Inferred only
UBE2N interacts with RNF152ProteinHetionet hetionet:interacts:220441-7334Inferred only
RNF152 participates in E3 ubiquitin ligases ubiquitinate target proteinsPathwayReactome R-HSA-8866654Inferred only
RNF152 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
RNF152 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
RNF152 participates in Protein ubiquitinationPathwayReactome R-HSA-8852135Inferred only

Show the remaining 2

RNF152 regulates negative regulation of TORC1 signalingBiological processgene ontology Q8N8N0|GO:1904262Inferred only
RNF152 regulates positive regulation of autophagyBiological processgene ontology Q8N8N0|GO:0010508Inferred only

Reactions

1 reaction

MAM00204c+ATP+MAM03105cMAM00214c+AMP+diphosphate(3-)
Catalysed by RNF40 & RNF20 or SAE1 & UBA2 or RING1 & RNF2 or HECW1 or MYCBP2 or MYLIP or UBE3C or RNF216 or UBR7 or RNF14 or UBR2

Other names

2 names

Resolves to: RNF152

Also called: RING finger protein 152RING-type E3 ubiquitin transferase RNF152

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