Proteins/UNIPROT:P58012

FOXL2

ProteinUNIPROT:P58012

Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2..

Function from UniProtKB (P58012), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

blepharophimosis, ptosis, and epicanthus inversus syndrome has a germline basis in FOXL2DiseaseGenCC HGNC:1092|MONDO:0007201Inferred only

Statements

35 statements

35 statements · 4 reference databases · Subject: FOXL2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

FOXL2 covaries with BICD1ProteinHetionet hetionet:covaries:636-668Inferred only
FOXL2 covaries with CAPNS1ProteinHetionet hetionet:covaries:668-826Inferred only
FOXL2 covaries with CCDC81ProteinHetionet hetionet:covaries:60494-668Inferred only
FOXL2 covaries with FZD4ProteinHetionet hetionet:covaries:668-8322Inferred only
FOXL2 covaries with GPR68ProteinHetionet hetionet:covaries:668-8111Inferred only
FOXL2 covaries with JUNProteinHetionet hetionet:covaries:3725-668Inferred only
LSM5 covaries with FOXL2ProteinHetionet hetionet:covaries:23658-668Inferred only
FOXL2 covaries with MINAR1ProteinHetionet hetionet:covaries:23251-668Inferred only
POLR2J covaries with FOXL2ProteinHetionet hetionet:covaries:5439-668Inferred only
FOXL2 covaries with PPFIA2ProteinHetionet hetionet:covaries:668-8499Inferred only
RAP2B covaries with FOXL2ProteinHetionet hetionet:covaries:5912-668Inferred only
FOXL2 covaries with RPLP1ProteinHetionet hetionet:covaries:6176-668Inferred only

Show the remaining 23

FOXL2 covaries with RPS13ProteinHetionet hetionet:covaries:6207-668Inferred only
SLC24A1 covaries with FOXL2ProteinHetionet hetionet:covaries:668-9187Inferred only
SLITRK3 covaries with FOXL2ProteinHetionet hetionet:covaries:22865-668Inferred only
TPM2 covaries with FOXL2ProteinHetionet hetionet:covaries:668-7169Inferred only
FOXL2 covaries with UBE2G2ProteinHetionet hetionet:covaries:668-7327Inferred only
FOXL2 interacts with LATS1ProteinHetionet hetionet:interacts:668-9113Inferred only
FOXL2 interacts with PAK1ProteinHetionet hetionet:interacts:5058-668Inferred only
FOXL2 interacts with SMAD3ProteinHetionet hetionet:interacts:4088-668Inferred only
FOXL2 interacts with SUMO1ProteinHetionet hetionet:interacts:668-7341Inferred only
FOXL2 interacts with UBE2IProteinHetionet hetionet:interacts:668-7329Inferred only
FOXL2 participates in Mammalian disorder of sexual developmentPathwayWikiPathways WP4842Inferred only
FOXL2 participates in MAP3K1 role in promoting and blocking gonadal determinationPathwayWikiPathways WP4872Inferred only
FOXL2 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
FOXL2 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
FOXL2 participates in Primary ovarian insufficiencyPathwayWikiPathways WP5461Inferred only
FOXL2 participates in Somatic sex determinationPathwayWikiPathways WP4814Inferred only
FOXL2 participates in SUMO E3 ligases SUMOylate target proteinsPathwayReactome R-HSA-3108232Inferred only
FOXL2 participates in SUMOylationPathwayReactome R-HSA-2990846Inferred only
FOXL2 participates in SUMOylation of transcription factorsPathwayReactome R-HSA-3232118Inferred only
FOXL2 regulates negative regulation of DNA-templated transcriptionBiological processgene ontology P58012|GO:0045892Inferred only
FOXL2 regulates positive regulation of apoptotic processBiological processgene ontology P58012|GO:0043065Inferred only
FOXL2 regulates positive regulation of DNA-templated transcriptionBiological processgene ontology P58012|GO:0045893Inferred only
FOXL2 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology P58012|GO:0006357Inferred only

Other names

1 name

Resolves to: FOXL2

Also called: Forkhead box protein L2

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