Proteins/UNIPROT:Q9Y450

HBS1L

ProteinUNIPROT:Q9Y450

GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway..

Function from UniProtKB (Q9Y450), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

retinal disorder has a germline basis in HBS1LDiseaseGenCC HGNC:4834|MONDO:0005283Inferred only

Statements

13 statements

13 statements · 2 reference databases · Subject: HBS1L · Sources: Hetionet, Reactome

Order

HBS1L covaries with CPOProteinHetionet hetionet:covaries:10767-130749Inferred only
APP interacts with HBS1LProteinHetionet hetionet:interacts:10767-351Inferred only
CUL3 interacts with HBS1LProteinHetionet hetionet:interacts:10767-8452Inferred only
HBS1L interacts with FANCIProteinHetionet hetionet:interacts:10767-55215Inferred only
SRPK1 interacts with HBS1LProteinHetionet hetionet:interacts:10767-6732Inferred only
SRPK2 interacts with HBS1LProteinHetionet hetionet:interacts:10767-6733Inferred only
UBC interacts with HBS1LProteinHetionet hetionet:interacts:10767-7316Inferred only
UBE2G2 interacts with HBS1LProteinHetionet hetionet:interacts:10767-7327Inferred only
HBS1L participates in Deadenylation-dependent mRNA decayPathwayReactome R-HSA-429914Inferred only
HBS1L participates in Metabolism of RNAPathwayReactome R-HSA-8953854Inferred only
HBS1L participates in mRNA decay by 3' to 5' exoribonucleasePathwayReactome R-HSA-429958Inferred only
ERBB2 decreases the expression of HBS1LProteinHetionet hetionet:regulates:2064-10767Inferred only

Show the remaining 1

HSF1 increases the expression of HBS1LProteinHetionet hetionet:regulates:3297-10767Inferred only

Reactions

1 reaction

GTP+waterGDP+hydrogenphosphate+hydron
Catalysed by IRGM or RAB19 or TUBAL3 or GTPBP1 or RAB27B or RHOD or DNM1L or MRAS or RAB29 or OPA1 or EIF5B or ENTPD3 and 183 more alternatives
Reaction page

Other names

3 names

Resolves to: HBS1L

Also called: ERFSHBS1KIAA1038

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