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Proteins/UNIPROT:O94887

FARP2

Protein·UNIPROT:O94887

Open in the graph

Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity)..

Function from UniProtKB (O94887), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

29 statements

29 statements · 4 reference databases · Subject: FARP2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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FARP2 covaries with FCN3ProteinHetionet hetionet:covaries:8547-9855Inferred only
FARP2 covaries with HDAC4ProteinHetionet hetionet:covaries:9759-9855Inferred only
FARP2 covaries with KNDC1ProteinHetionet hetionet:covaries:85442-9855Inferred only
FARP2 covaries with PER2ProteinHetionet hetionet:covaries:8864-9855Inferred only
THAP4 covaries with FARP2ProteinHetionet hetionet:covaries:51078-9855Inferred only
FARP2 covaries with TUBGCP2ProteinHetionet hetionet:covaries:10844-9855Inferred only
PDZK1 interacts with FARP2ProteinHetionet hetionet:interacts:5174-9855Inferred only
SRC interacts with FARP2ProteinHetionet hetionet:interacts:6714-9855Inferred only
UBC interacts with FARP2ProteinHetionet hetionet:interacts:7316-9855Inferred only
UBE2G2 interacts with FARP2ProteinHetionet hetionet:interacts:7327-9855Inferred only
FARP2 participates in 2q37 copy number variation syndromePathwayWikiPathways WP5224Inferred only
FARP2 participates in Activation of STAT3 by cadherin engagementPathwayReactome R-HSA-9958825Inferred only

Show the remaining 17

FARP2 participates in Adherens junctions interactionsPathwayReactome R-HSA-418990Inferred only
FARP2 participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
FARP2 participates in Cell junction organizationPathwayReactome R-HSA-446728Inferred only
FARP2 participates in Cell-Cell communicationPathwayReactome R-HSA-1500931Inferred only
FARP2 participates in Cell-cell junction organizationPathwayReactome R-HSA-421270Inferred only
FARP2 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
FARP2 participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
FARP2 participates in RAC1 GTPase cyclePathwayReactome R-HSA-9013149Inferred only
FARP2 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
FARP2 participates in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesionPathwayReactome R-HSA-399955Inferred only
FARP2 participates in Semaphorin interactionsPathwayReactome R-HSA-373755Inferred only
FARP2 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
FARP2 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
FARP2 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
FARP2 participates in SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST)PathwayReactome R-HSA-9958810Inferred only
FARP2 participates in TAR syndromePathwayWikiPathways WP5362Inferred only
FARP2 regulates regulation of integrin activationBiological processgene ontology O94887|GO:0033623Inferred only

Other names

7 names

Resolves to: FARP2

Also called: FERM domain-including RhoGEFFERM, RhoGEF and pleckstrin domain-containing protein 2FIRKIAA0793PH domain-containing family C member 3Pleckstrin homology domain-containing family C member 3PLEKHC3

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