Proteins/UNIPROT:Q9H252

KCNH6

ProteinUNIPROT:Q9H252Voltage-gated inwardly rectifying potassium channel KCNH6

Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization. Activates even more slowly than KCNH2..

Function from UniProtKB (Q9H252), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

13 statements

13 statements · 4 reference databases · Subject: KCNH6 · Sources: gene ontology, Hetionet, Reactome, Rhea

Order

ATP5F1A covaries with KCNH6ProteinHetionet hetionet:covaries:498-81033Inferred only
KCNH6 covaries with CIAO2AProteinHetionet hetionet:covaries:81033-84191Inferred only
GABRR2 covaries with KCNH6ProteinHetionet hetionet:covaries:2570-81033Inferred only
KCNH6 covaries with MTFMTProteinHetionet hetionet:covaries:123263-81033Inferred only
KCNH6 covaries with OTX2ProteinHetionet hetionet:covaries:5015-81033Inferred only
SVEP1 covaries with KCNH6ProteinHetionet hetionet:covaries:79987-81033Inferred only
KCNH6 covaries with TK2ProteinHetionet hetionet:covaries:7084-81033Inferred only
KCNH6 participates in Neuronal SystemPathwayReactome R-HSA-112316Inferred only
KCNH6 participates in Potassium ChannelsPathwayReactome R-HSA-1296071Inferred only
KCNH6 participates in Voltage gated Potassium channelsPathwayReactome R-HSA-1296072Inferred only
KCNH6 regulates regulation of heart rate by cardiac conductionBiological processgene ontology Q9H252|GO:0086091Inferred only
KCNH6 regulates regulation of ventricular cardiac muscle cell membrane repolarizationBiological processgene ontology Q9H252|GO:0060307Inferred only

Show the remaining 1

K(+) is transported by KCNH6CompoundRhea RHEA:29463Inferred only

Reactions

1 reaction

K(+)K(+)
Transported by ANO9 or HTR3E or KCNU1 or KCNJ18 or TMEM150C or KCNK1 or KCNK3 or GRIN2D or KCNN4 or KCNQ3 or KCNQ2 or HCN1 and 136 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:29463CC BY 4.0Reference data

Other names

9 names

Resolves to: KCNH6

Also called: Eag-related protein 2ERG-2ERG2Ether-a-go-go-related gene potassium channel 2Ether-a-go-go-related protein 2hERG-2hERG2Potassium voltage-gated channel subfamily H member 6Voltage-gated potassium channel subunit Kv11.2

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