Pathway
Insulin receptor signalling cascade
Autophosphorylation of the insulin receptor triggers a series of signalling events, mediated by SHC or IRS, and resulting in activation of the Ras/RAF and MAP kinase cascades. A second effect of the autophosphorylation of the insulin receptor is its internalisation into an endosome, which downregulates its signalling activity.
REACT:R-HSA-74751Reactome
What the reference databases state
Statements
45 statements
45 statements · 1 reference database · Subject: Insulin receptor signalling cascade · Sources: Reactome
- AKT2 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- FGF1 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- FGF10 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- FGF16 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- FGF18 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- FGF19 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- FGF2 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- FGF20 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- FGF22 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- FGF23 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- FGF3 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- FGF4 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
Show the remaining 33
- FGF6 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- FGF7 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- FGF9 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- FGFR4 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- FLT3 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- FLT3LG participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- FRS2 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- GAB1 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- GAB2 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- GRB10 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- HRAS participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- INS participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- INSR participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- IRS1 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- IRS2 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- KLB participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- MAPK1 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- MAPK3 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- NRAS participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- PDE3B participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- PDPK1 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- PIK3C3 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- PIK3CA participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- PIK3CB participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- PIK3R1 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- PIK3R2 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- PIK3R4 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- PTPN11 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- SHC1 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- SOS1 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- THEM4 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- TLR9 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only
- TRIB3 participates in Insulin receptor signalling cascadeProteinReactome R-HSA-74751Inferred only