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© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:P11277

SPTB

Protein·UNIPROT:P11277

Open in the graph

Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.

Function from UniProtKB (P11277), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

4 rows

elliptocytosis 3 has a germline basis in SPTBDiseaseGenCC HGNC:11274|MONDO:0054780Inferred only
hereditary elliptocytosis has a germline basis in SPTBDiseaseGenCC HGNC:11274|MONDO:0017319Inferred only
hereditary spherocytosis has a germline basis in SPTBDiseaseGenCC HGNC:11274|MONDO:0019350Inferred only
hereditary spherocytosis type 2 has a germline basis in SPTBDiseaseGenCC HGNC:11274|MONDO:0000913Inferred only

Statements

40 statements

40 statements · 3 reference databases · Subject: SPTB · Sources: gene ontology, Hetionet, Reactome

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ANK1 covaries with SPTBProteinHetionet hetionet:covaries:286-6710Inferred only
ATPSCKMT covaries with SPTBProteinHetionet hetionet:covaries:134145-6710Inferred only
GZMK covaries with SPTBProteinHetionet hetionet:covaries:3003-6710Inferred only
SPTB covaries with KRT86ProteinHetionet hetionet:covaries:3892-6710Inferred only
KRTAP2-1 covaries with SPTBProteinHetionet hetionet:covaries:6710-728279Inferred only
LDLRAD4 covaries with SPTBProteinHetionet hetionet:covaries:6710-753Inferred only
SORCS2 covaries with SPTBProteinHetionet hetionet:covaries:57537-6710Inferred only
SPTB covaries with SPTA1ProteinHetionet hetionet:covaries:6708-6710Inferred only
TRPV6 covaries with SPTBProteinHetionet hetionet:covaries:55503-6710Inferred only
ADD1 interacts with SPTBProteinHetionet hetionet:interacts:118-6710Inferred only
AP1G1 interacts with SPTBProteinHetionet hetionet:interacts:164-6710Inferred only
SPTB interacts with CSRP3ProteinHetionet hetionet:interacts:6710-8048Inferred only

Show the remaining 28

DMTN interacts with SPTBProteinHetionet hetionet:interacts:2039-6710Inferred only
ENO3 interacts with SPTBProteinHetionet hetionet:interacts:2027-6710Inferred only
EPB41 interacts with SPTBProteinHetionet hetionet:interacts:2035-6710Inferred only
NCAM1 interacts with SPTBProteinHetionet hetionet:interacts:4684-6710Inferred only
SPTB interacts with SNAPINProteinHetionet hetionet:interacts:23557-6710Inferred only
SPTA1 interacts with SPTBProteinHetionet hetionet:interacts:6708-6710Inferred only
SPTAN1 interacts with SPTBProteinHetionet hetionet:interacts:6709-6710Inferred only
SPTB interacts with TULP3ProteinHetionet hetionet:interacts:6710-7289Inferred only
SPTB interacts with UBCProteinHetionet hetionet:interacts:6710-7316Inferred only
SPTB participates in Asparagine N-linked glycosylationPathwayReactome R-HSA-446203Inferred only
SPTB participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
SPTB participates in COPI-mediated anterograde transportPathwayReactome R-HSA-6807878Inferred only
SPTB participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
SPTB participates in ER to Golgi Anterograde TransportPathwayReactome R-HSA-199977Inferred only
SPTB participates in Interaction between L1 and AnkyrinsPathwayReactome R-HSA-445095Inferred only
SPTB participates in L1CAM interactionsPathwayReactome R-HSA-373760Inferred only
SPTB participates in MAPK family signaling cascadesPathwayReactome R-HSA-5683057Inferred only
SPTB participates in MAPK1/MAPK3 signalingPathwayReactome R-HSA-5684996Inferred only
SPTB participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
SPTB participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
SPTB participates in NCAM signaling for neurite out-growthPathwayReactome R-HSA-375165Inferred only
SPTB participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
SPTB participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
SPTB participates in RAF/MAP kinase cascadePathwayReactome R-HSA-5673001Inferred only
SPTB participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
SPTB participates in Transport to the Golgi and subsequent modificationPathwayReactome R-HSA-948021Inferred only
SPTB participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
SPTB regulates regulation of cell shapeBiological processgene ontology P11277|GO:0008360Inferred only

Other names

3 names

Resolves to: SPTB

Also called: Beta-I spectrinSpectrin beta chain, erythrocyticSPTB1

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