Pathway
Creatine metabolism
In humans, creatine is synthesized primarily in the liver and kidney, from glycine, arginine, and S-adenosylmethionine, in a sequence of two reactions. From the liver, creatine is exported to tissues such as skeletal muscle and brain, where it undergoes phosphorylation and serves as a short-term energy store. The mechanism by which creatine leaves producer tissues is unclear, but its uptake by consumer tissues is mediated by the SLC6A8 transporter.
Continue reading
Once formed, phosphocreatine undergoes a slow spontaneous reaction to form creatinine, which is excreted from the body.
REACT:R-HSA-71288Reactome
What the reference databases state
Statements
10 statements
10 statements · 1 reference database · Subject: Creatine metabolism · Sources: Reactome
- CKB participates in Creatine metabolismProteinReactome R-HSA-71288Inferred only
- CKM participates in Creatine metabolismProteinReactome R-HSA-71288Inferred only
- CKMT1A participates in Creatine metabolismProteinReactome R-HSA-71288Inferred only
- CKMT2 participates in Creatine metabolismProteinReactome R-HSA-71288Inferred only
- GAMT participates in Creatine metabolismProteinReactome R-HSA-71288Inferred only
- GATM participates in Creatine metabolismProteinReactome R-HSA-71288Inferred only
- SLC6A11 participates in Creatine metabolismProteinReactome R-HSA-71288Inferred only
- SLC6A12 participates in Creatine metabolismProteinReactome R-HSA-71288Inferred only
- SLC6A7 participates in Creatine metabolismProteinReactome R-HSA-71288Inferred only
- SLC6A8 participates in Creatine metabolismProteinReactome R-HSA-71288Inferred only