Proteins/UNIPROT:P12035

KRT3

ProteinUNIPROT:P12035

Structural component of intermediate filaments in the corneal epithelium. Forms heteropolymers with the type I keratin KRT12, assembling into keratin intermediate filament networks that provide mechanical strength and structural integrity to the corneal epithelial layer..

Function from UniProtKB (P12035), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

3 rows

corneal dystrophy, Meesmann, 1 has a germline basis in KRT3DiseaseGenCC HGNC:6440|MONDO:0020791Inferred only
corneal dystrophy, Meesmann, 2 has a germline basis in KRT3DiseaseGenCC HGNC:6440|MONDO:0032904Inferred only
Meesmann corneal dystrophy has a germline basis in KRT3DiseaseGenCC HGNC:6440|MONDO:0007379Inferred only

Statements

12 statements

12 statements · 2 reference databases · Subject: KRT3 · Sources: Hetionet, Reactome

Order

OAS3 covaries with KRT3ProteinHetionet hetionet:covaries:3850-4940Inferred only
OR51D1 covaries with KRT3ProteinHetionet hetionet:covaries:3850-390038Inferred only
SLC47A2 covaries with KRT3ProteinHetionet hetionet:covaries:146802-3850Inferred only
TXNDC16 covaries with KRT3ProteinHetionet hetionet:covaries:3850-57544Inferred only
ZNF16 covaries with KRT3ProteinHetionet hetionet:covaries:3850-7564Inferred only
ZNF789 covaries with KRT3ProteinHetionet hetionet:covaries:285989-3850Inferred only
KRT3 interacts with COPS5ProteinHetionet hetionet:interacts:10987-3850Inferred only
KRT3 interacts with CUL5ProteinHetionet hetionet:interacts:3850-8065Inferred only
KRT3 interacts with UBCProteinHetionet hetionet:interacts:3850-7316Inferred only
KRT3 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
KRT3 participates in Formation of the cornified envelopePathwayReactome R-HSA-6809371Inferred only
KRT3 participates in KeratinizationPathwayReactome R-HSA-6805567Inferred only

Other names

6 names

Resolves to: KRT3

Also called: 65 kDa cytokeratinCK-3Cytokeratin-3K3Keratin-3Type-II keratin Kb3

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