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Proteins/UNIPROT:O00337
Sodium and pyrimidine nucleoside symporter of the plasma membrane that imports uridine, thymidine and cytidine into cells by coupling their transport to the transmembrane sodium electrochemical gradient. Also transports adenosine, an atypical substrate transported with high apparent affinity, but low maximum velocity. Therefore, exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit). Involved in renal nucleoside (re)absorption..
Function from UniProtKB (O00337), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
31 statements
31 statements · 5 reference databases · Subject: SLC28A1 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
11 reactions
adenosine+sodium(1+)adenosine+sodium(1+)
Transported by SLC28A2 or SLC28A1 or SLC28A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR04845CC BY 4.0Reference data
sodium(1+)+thymidinesodium(1+)+thymidine
Transported by SLC28A1
7 names
Resolves to: SLC28A1
Human-GEM MAR04983CC BY 4.0Reference data
cytidine+sodium(1+)cytidine+sodium(1+)
Transported by SLC28A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05038CC BY 4.0Reference data
2'-deoxyadenosine+sodium(1+)2'-deoxyadenosine+sodium(1+)
Transported by SLC28A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05039CC BY 4.0Reference data
2'-deoxycytidine+sodium(1+)2'-deoxycytidine+sodium(1+)
Transported by SLC28A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05040CC BY 4.0Reference data
sodium(1+)+uridinesodium(1+)+uridine
Transported by SLC28A2 or SLC28A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06351CC BY 4.0Reference data
2'-deoxyuridine+sodium(1+)2'-deoxyuridine+sodium(1+)
Transported by SLC28A2 or SLC28A1 or SLC28A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06352CC BY 4.0Reference data
uridine+sodium(1+)uridine+sodium(1+)
Transported by SLC28A1 or SLC28A2
Reaction pageDirection not assertedBalanced
Rhea RHEA:69887CC BY 4.0Reference data
thymidine+sodium(1+)thymidine+sodium(1+)
Transported by SLC28A1
Reaction pageDirection not assertedBalanced
Rhea RHEA:69891CC BY 4.0Reference data
cytidine+sodium(1+)cytidine+sodium(1+)
Transported by SLC28A1
Reaction pageDirection not assertedBalanced
Rhea RHEA:69895CC BY 4.0Reference data
adenosine+sodium(1+)adenosine+sodium(1+)
Transported by SLC28A1 or SLC28A2
Reaction pageDirection not assertedBalanced
Rhea RHEA:69927CC BY 4.0Reference data