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Proteins/UNIPROT:Q9H2X9
Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation..
Function from UniProtKB (Q9H2X9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
2 rows
56 statements
56 statements · 8 reference databases · Subject: SLC12A5 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
2 reactions
chlorine(.)+potassium atomchlorine(.)+potassium atom
Transported by SLC12A7 or SLC12A4 or SLC12A5 or SLC12A6
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05990CC BY 4.0Reference data
Transported by SLC12A5
6 names
Resolves to: SLC12A5
Reaction pageDirection not assertedBalanced
Rhea RHEA:72427CC BY 4.0Reference data