Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:Q92529

SHC3

Protein·UNIPROT:Q92529

Open in the graph

Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.

Function from UniProtKB (Q92529), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

40 statements

40 statements · 3 reference databases · Subject: SHC3 · Sources: Hetionet, Reactome, WikiPathways

Search this listOrder

OR1D5 covaries with SHC3ProteinHetionet hetionet:covaries:53358-8386Inferred only
SHC3 covaries with SERTAD3ProteinHetionet hetionet:covaries:29946-53358Inferred only
SHC3 covaries with ZNF432ProteinHetionet hetionet:covaries:53358-9668Inferred only
ALK interacts with SHC3ProteinHetionet hetionet:interacts:238-53358Inferred only
APP interacts with SHC3ProteinHetionet hetionet:interacts:351-53358Inferred only
ARHGAP32 interacts with SHC3ProteinHetionet hetionet:interacts:53358-9743Inferred only
AXL interacts with SHC3ProteinHetionet hetionet:interacts:53358-558Inferred only
EGFR interacts with SHC3ProteinHetionet hetionet:interacts:1956-53358Inferred only
ERBB2 interacts with SHC3ProteinHetionet hetionet:interacts:2064-53358Inferred only
ERBB3 interacts with SHC3ProteinHetionet hetionet:interacts:2065-53358Inferred only
FLT4 interacts with SHC3ProteinHetionet hetionet:interacts:2324-53358Inferred only
GRB2 interacts with SHC3ProteinHetionet hetionet:interacts:2885-53358Inferred only

Show the remaining 28

NTRK1 interacts with SHC3ProteinHetionet hetionet:interacts:4914-53358Inferred only
NTRK2 interacts with SHC3ProteinHetionet hetionet:interacts:4915-53358Inferred only
RET interacts with SHC3ProteinHetionet hetionet:interacts:53358-5979Inferred only
SH3GL3 interacts with SHC3ProteinHetionet hetionet:interacts:53358-6457Inferred only
SHC3 participates in Angiopoietin like protein 8 regulatory pathwayPathwayWikiPathways WP3915Inferred only
SHC3 participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
SHC3 participates in Brain derived neurotrophic factor BDNF signalingPathwayWikiPathways WP2380Inferred only
SHC3 participates in Breast cancer pathwayPathwayWikiPathways WP4262Inferred only
SHC3 participates in Chemokine signalingPathwayWikiPathways WP3929Inferred only
SHC3 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
SHC3 participates in Effect of dasatinib on the BCR ABL signaling pathwayPathwayWikiPathways WP5493Inferred only
SHC3 participates in EGFR tyrosine kinase inhibitor resistancePathwayWikiPathways WP4806Inferred only
SHC3 participates in ErbB signalingPathwayWikiPathways WP673Inferred only
SHC3 participates in Focal adhesionPathwayWikiPathways WP306Inferred only
SHC3 participates in Insulin signalingPathwayWikiPathways WP481Inferred only
SHC3 participates in Integrin mediated cell adhesionPathwayWikiPathways WP185Inferred only
SHC3 participates in MAPK family signaling cascadesPathwayReactome R-HSA-5683057Inferred only
SHC3 participates in MAPK1/MAPK3 signalingPathwayReactome R-HSA-5684996Inferred only
SHC3 participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
SHC3 participates in RAF/MAP kinase cascadePathwayReactome R-HSA-5673001Inferred only
SHC3 participates in Ras signalingPathwayWikiPathways WP4223Inferred only
SHC3 participates in RET signalingPathwayReactome R-HSA-8853659Inferred only
SHC3 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
SHC3 participates in Signaling by NTRK1 (TRKA)PathwayReactome R-HSA-187037Inferred only
SHC3 participates in Signaling by NTRKsPathwayReactome R-HSA-166520Inferred only
SHC3 participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
SHC3 participates in Signalling to ERKsPathwayReactome R-HSA-187687Inferred only
SHC3 participates in Signalling to RASPathwayReactome R-HSA-167044Inferred only

Other names

8 names

Resolves to: SHC3

Also called: N-ShcNeuronal ShcNSHCProtein RaiSH2 domain protein C3SHC-transforming protein CSHCCSrc homology 2 domain-containing-transforming protein C3

← Every protein Find it in the graph →