PapersPMID:40404584
Sodium Benzoate Inhibits Osteoblast Differentiation and Accelerates Bone Loss by Regulating the FGF2/p38/RUNX2 Pathway.
- 01 · finding
- 1
- 02 · compound
- 1
- 03 · endpoint
- 1
- 04 · null
- 0
What moved
1 findingHow to read these marks →sodium benzoate — inhibits RUNX2
insufficientFinding
“The rescue studies suggested that NaB inhibited RUNX2 expression and osteoblast differentiation through the p38/MAPK signaling pathway.”
Quoted verbatim from Sodium Benzoate Inhibits Osteoblast Differentiation and Accelerates Bone Loss by Regulating the FGF2/p38/RUNX2 Pathway. - Study
- in vitro · not in humans
- Population
- bone marrow mesenchymal stem cells and MC3T3-E1 osteoblast-lineage cells
Study record
- Read under
- sodium benzoate
- Design
- animal study, in vivo
- Species
- mixed
- Population
- Female C57BL/6J mice (in vivo); rat BMSCs and MC3T3-E1 preosteoblast cells (in vitro)
- Participants
- 30
- Comparator
- placebo
- Duration
- not recorded
- Endpoints measured
- 17
- Record
- extracted
- Readings recorded
- 3