Coenzyme A biosynthesis

Coenzyme A (CoA) is a ubiquitous cofactor that functions as an acyl group carrier in diverse processes including fatty acid metabolism and the TCA cycle. It is synthesized from the vitamin pantothenate in a sequence of five reactions. These reactions all occur in the cytosol or the mitochondrial intermembrane space. A recently described transport protein appears to mediate the uptake of Coenzyme A into the mitochondrial matrix.

Summary from Reactome (R-HSA-196783), read 2026-09-23.