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Proteins/UNIPROT:Q15751
Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates..
Function from UniProtKB (Q15751), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
27 statements
27 statements · 2 reference databases · Subject: HERC1 · Sources: Hetionet, Reactome
1 reaction
4 names
Resolves to: HERC1
Reaction pageLeft to rightBalance undeterminableEC 2.3.2.23, 2.3.2.27, 6.2.1.45cytosol
Human-GEM MAR09491CC BY 4.0Reference data