Proteins/UNIPROT:Q8IY63

AMOTL1

ProteinUNIPROT:Q8IY63

Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus..

Function from UniProtKB (Q8IY63), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

orofacial cleft has a germline basis in AMOTL1DiseaseGenCC HGNC:17811|MONDO:0000358Inferred only
orofacial clefting-cardiac anomalies-facial dysmorphism syndrome has a germline basis in AMOTL1DiseaseGenCC HGNC:17811|MONDO:0971064Inferred only

Statements

14 statements

14 statements · 3 reference databases · Subject: AMOTL1 · Sources: gene ontology, Hetionet, Reactome

Order

ANKRD34C covaries with AMOTL1ProteinHetionet hetionet:covaries:154810-390616Inferred only
AMOTL1 covaries with FAT3ProteinHetionet hetionet:covaries:120114-154810Inferred only
HOXC12 covaries with AMOTL1ProteinHetionet hetionet:covaries:154810-3228Inferred only
MAML2 covaries with AMOTL1ProteinHetionet hetionet:covaries:154810-84441Inferred only
NLRC4 covaries with AMOTL1ProteinHetionet hetionet:covaries:154810-58484Inferred only
RPL35A covaries with AMOTL1ProteinHetionet hetionet:covaries:154810-6165Inferred only
SCRT2 covaries with AMOTL1ProteinHetionet hetionet:covaries:154810-85508Inferred only
SNORC covaries with AMOTL1ProteinHetionet hetionet:covaries:154810-389084Inferred only
ZNF699 covaries with AMOTL1ProteinHetionet hetionet:covaries:154810-374879Inferred only
NEDD4L interacts with AMOTL1ProteinHetionet hetionet:interacts:154810-23327Inferred only
UBC interacts with AMOTL1ProteinHetionet hetionet:interacts:154810-7316Inferred only
AMOTL1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only

Show the remaining 2

AMOTL1 participates in Signaling by HippoPathwayReactome R-HSA-2028269Inferred only
AMOTL1 regulates regulation of cell migrationBiological processgene ontology Q8IY63|GO:0030334Inferred only

Other names

1 name

Resolves to: AMOTL1

Also called: Angiomotin-like protein 1

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