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Proteins/UNIPROT:P46059
Electrogenic proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides. Transports neutral and monovalently charged peptides with a proton to peptide stoichiometry of 1:1 or 2:1 (By similarity). Primarily responsible for the absorption of dietary di- and tripeptides from the small intestinal lumen (By similarity). Mediates transepithelial transport of muramyl and N-formylated bacterial dipeptides contributing to recognition of pathogenic bacteria by the mucosal immune system..
Function from UniProtKB (P46059), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
300 statements
300 statements · 5 reference databases · Subject: SLC15A1 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea
282 reactions
proton+D-alanyl-D-alanineproton+D-alanyl-D-alanine
Transported by SLC15A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06862CC BY 4.0Reference data
CHEBI:15727+protonCHEBI:15727+proton
Transported by SLC15A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
4 names
Resolves to: SLC15A1
MAM03621eMAM03621c
Transported by SLC15A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06899CC BY 4.0Reference data
proton+MAM03629eproton+MAM03629c
Transported by SLC15A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06900CC BY 4.0Reference data
proton+CHEBI:356660proton+CHEBI:356660
Transported by SLC15A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06913CC BY 4.0Reference data
proton+glycyl-sarcosineproton+glycyl-sarcosine
Transported by SLC15A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06917CC BY 4.0Reference data
proton+MAM03714eproton+MAM03714c
Transported by SLC15A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR07148CC BY 4.0Reference data
proton+MAM03715eproton+MAM03715c
Transported by SLC15A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR07150CC BY 4.0Reference data
proton+MAM03896eproton+MAM03896c
Transported by SLC15A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR07192CC BY 4.0Reference data
L-cysteinylglycine+2protonL-cysteinylglycine+2proton
Transported by SLC15A1 or SLC15A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR07680CC BY 4.0Reference data
5-aminolevulinic acid+2proton5-aminolevulinic acid+2proton
Transported by SLC15A1
Reaction pageReversibleBalancedEC 3.1.1.4cytosol, extracellular space
Human-GEM MAR09985CC BY 4.0Reference data
proton+MAM03411eproton+MAM03411c
Transported by SLC15A1 or SLC15A2
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR10739CC BY 4.0Reference data