Proteins/UNIPROT:Q9C056

NKX6-2

ProteinUNIPROT:Q9C056

Transcription factor with repressor activity involved in the regulation of axon-glial interactions at myelin paranodes in oligodendrocytes. Binds to the consensus DNA sequence 5'-(A/T)TTAATGA-3'. In oligodendrocytes, binds to MBP and PLP1 promoter regions..

Function from UniProtKB (Q9C056), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

spastic ataxia 8, autosomal recessive, with hypomyelinating leukodystrophy has a germline basis in NKX6-2DiseaseGenCC HGNC:19321|MONDO:0033043Inferred only

Statements

22 statements

22 statements · 3 reference databases · Subject: NKX6-2 · Sources: gene ontology, Hetionet, WikiPathways

Order

AMIGO2 covaries with NKX6-2ProteinHetionet hetionet:covaries:347902-84504Inferred only
ARL15 covaries with NKX6-2ProteinHetionet hetionet:covaries:54622-84504Inferred only
DMRTC2 covaries with NKX6-2ProteinHetionet hetionet:covaries:63946-84504Inferred only
DNAJA1 covaries with NKX6-2ProteinHetionet hetionet:covaries:3301-84504Inferred only
GPM6B covaries with NKX6-2ProteinHetionet hetionet:covaries:2824-84504Inferred only
HOXC5 covaries with NKX6-2ProteinHetionet hetionet:covaries:3222-84504Inferred only
LGALS1 covaries with NKX6-2ProteinHetionet hetionet:covaries:3956-84504Inferred only
MAPK8IP1 covaries with NKX6-2ProteinHetionet hetionet:covaries:84504-9479Inferred only
MTDH covaries with NKX6-2ProteinHetionet hetionet:covaries:84504-92140Inferred only
NIN covaries with NKX6-2ProteinHetionet hetionet:covaries:51199-84504Inferred only
NPL covaries with NKX6-2ProteinHetionet hetionet:covaries:80896-84504Inferred only
PALS2 covaries with NKX6-2ProteinHetionet hetionet:covaries:51678-84504Inferred only

Show the remaining 10

RAB11B covaries with NKX6-2ProteinHetionet hetionet:covaries:84504-9230Inferred only
NKX6-2 covaries with SFXN3ProteinHetionet hetionet:covaries:81855-84504Inferred only
SST covaries with NKX6-2ProteinHetionet hetionet:covaries:6750-84504Inferred only
NKX6-2 covaries with TPRProteinHetionet hetionet:covaries:7175-84504Inferred only
ZNF142 covaries with NKX6-2ProteinHetionet hetionet:covaries:7701-84504Inferred only
NKX6-2 participates in Integrative Analysis of Treg Glial Interactions PathwayWikiPathways WP5561Inferred only
NKX6-2 regulates negative regulation of DNA-templated transcriptionBiological processgene ontology Q9C056|GO:0045892Inferred only
NKX6-2 regulates regulation of DNA-templated transcriptionBiological processgene ontology Q9C056|GO:0006355Inferred only
NKX6-2 regulates regulation of myelinationBiological processgene ontology Q9C056|GO:0031641Inferred only
NKX6-2 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q9C056|GO:0006357Inferred only

Other names

4 names

Resolves to: NKX6-2

Also called: GTXHomeobox protein NK-6 homolog BHomeobox protein Nkx-6.2NKX6B

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