Pathway

HHAT G278V doesn't palmitoylate Hh-Np

A loss-of-function mutation in HHAT that abrogates palmitoylation of Hh ligand is associated with Syndromic 46, XY Disorder of Sex Development, which results in testis dysgenesis.

Summary from Reactome (R-HSA-5658034), read 2026-09-23.

REACT:R-HSA-5658034Reactome

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What the reference databases state

Statements

4 statements

4 statements · 1 reference database · Subject: HHAT G278V doesn't palmitoylate Hh-Np · Sources: Reactome

Order

DHH participates in HHAT G278V doesn't palmitoylate Hh-NpProteinReactome R-HSA-5658034Inferred only
HHAT participates in HHAT G278V doesn't palmitoylate Hh-NpProteinReactome R-HSA-5658034Inferred only
IHH participates in HHAT G278V doesn't palmitoylate Hh-NpProteinReactome R-HSA-5658034Inferred only
SHH participates in HHAT G278V doesn't palmitoylate Hh-NpProteinReactome R-HSA-5658034Inferred only