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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q9Y698

CACNG2

Protein·UNIPROT:Q9Y698

Open in the graph

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state..

Function from UniProtKB (Q9Y698), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

autosomal dominant non-syndromic intellectual disability has a germline basis in CACNG2DiseaseGenCC HGNC:1406|MONDO:0015802Inferred only

Statements

27 statements

27 statements · 4 reference databases · Subject: CACNG2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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CACNG2 covaries with ARF6ProteinHetionet hetionet:covaries:10369-382Inferred only
FRRS1L covaries with CACNG2ProteinHetionet hetionet:covaries:10369-23732Inferred only
CACNG2 covaries with GJA8ProteinHetionet hetionet:covaries:10369-2703Inferred only
APP interacts with CACNG2ProteinHetionet hetionet:interacts:10369-351Inferred only
DLG1 interacts with CACNG2ProteinHetionet hetionet:interacts:10369-1739Inferred only
DLG2 interacts with CACNG2ProteinHetionet hetionet:interacts:10369-1740Inferred only
DLG3 interacts with CACNG2ProteinHetionet hetionet:interacts:10369-1741Inferred only
DLG4 interacts with CACNG2ProteinHetionet hetionet:interacts:10369-1742Inferred only
GRIA1 interacts with CACNG2ProteinHetionet hetionet:interacts:10369-2890Inferred only
GRIA4 interacts with CACNG2ProteinHetionet hetionet:interacts:10369-2893Inferred only
PRKACA interacts with CACNG2ProteinHetionet hetionet:interacts:10369-5566Inferred only
SRPK2 interacts with CACNG2ProteinHetionet hetionet:interacts:10369-6733Inferred only

Show the remaining 15

CACNG2 participates in Arrhythmogenic right ventricular cardiomyopathyPathwayWikiPathways WP2118Inferred only
CACNG2 participates in Cell lineage map for neuronal differentiationPathwayWikiPathways WP5417Inferred only
CACNG2 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
CACNG2 participates in GABA and glutamate signalling in epileptogenesisPathwayWikiPathways WP5600Inferred only
CACNG2 participates in Glutamate binding, activation of AMPA receptors and synaptic plasticityPathwayReactome R-HSA-399721Inferred only
CACNG2 participates in LGI-ADAM interactionsPathwayReactome R-HSA-5682910Inferred only
CACNG2 participates in MAPK signalingPathwayWikiPathways WP382Inferred only
CACNG2 participates in Neuronal SystemPathwayReactome R-HSA-112316Inferred only
CACNG2 participates in Neurotransmitter receptors and postsynaptic signal transmissionPathwayReactome R-HSA-112314Inferred only
CACNG2 participates in Presynaptic depolarization and calcium channel openingPathwayReactome R-HSA-112308Inferred only
CACNG2 participates in Trafficking of AMPA receptorsPathwayReactome R-HSA-399719Inferred only
CACNG2 participates in Transmission across Chemical SynapsesPathwayReactome R-HSA-112315Inferred only
CACNG2 regulates positive regulation of protein localization to basolateral plasma membraneBiological processgene ontology Q9Y698|GO:1904510Inferred only
CACNG2 regulates positive regulation of synaptic transmission, glutamatergicBiological processgene ontology Q9Y698|GO:0051968Inferred only
CACNG2 regulates regulation of AMPA receptor activityBiological processgene ontology Q9Y698|GO:2000311Inferred only

Other names

3 names

Resolves to: CACNG2

Also called: Neuronal voltage-gated calcium channel gamma-2 subunitTARP gamma-2Transmembrane AMPAR regulatory protein gamma-2

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