Pathway
Protein-protein interactions at synapses
Synapses constitute highly specialized sites of asymmetric cell-cell adhesion and intercellular communication. Its formation involves the recruitment of presynaptic and postsynaptic molecules at newly formed contacts. Synapse assembly and maintenance invokes heterophilic presynaptic and postsynaptic transmembrane proteins that bind each other in the extracellular space and recruit additional proteins via their intracellular domains. Members of the cadherin and immunoglobulin (Ig) superfamilies are thought to mediate this function. Several molecules, including synaptic cell-adhesion molecule (SynCAM), N-cadherin, neural cell-adhesion molecule (NCAM), Eph receptor tyrosine kinases, and neuroligins and neurexins, have been implicated in synapse formation and maintenance.
REACT:R-HSA-6794362Reactome
What the reference databases state
Statements
84 statements
84 statements · 1 reference database · Subject: Protein-protein interactions at synapses · Sources: Reactome
- APBA1 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- APBA2 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- APBA3 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- BEGAIN participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- CASK participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- DBNL participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- DLG1 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- DLG2 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- DLG3 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- DLG4 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- DLGAP1 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- DLGAP3 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
Show the remaining 72
- DLGAP4 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- EPB41 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- EPB41L1 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- EPB41L2 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- EPB41L3 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- EPB41L5 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- FLOT1 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- FLOT2 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- GRIA1 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- GRIA3 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- GRIA4 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- GRIN1 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- GRIN2A participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- GRIN2B participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- GRIN2C participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- GRIN2D participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- GRM1 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- GRM5 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- HOMER1 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- HOMER2 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- HOMER3 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- IL1RAPL1 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- IL1RAPL2 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- LIN7A participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- LIN7B participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- LIN7C participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- LRFN1 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- LRFN2 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- LRFN3 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- LRFN4 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- LRRC4B participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- LRRTM1 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- LRRTM2 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- LRRTM4 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- NLGN1 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- NLGN2 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- NLGN3 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- NLGN4X participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- NRXN1 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- NRXN2 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- NRXN3 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- NTRK3 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- PDLIM5 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- PPFIA1 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- PPFIA2 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- PPFIA3 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- PPFIA4 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- PPFIBP1 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- PPFIBP2 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- PTPRD participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- PTPRF participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- PTPRS participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- RTN3 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- SHANK1 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- SHANK2 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- SHANK3 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- SHARPIN participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- SIPA1L1 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- SLITRK1 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- SLITRK2 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- SLITRK3 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- SLITRK4 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- SLITRK5 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- SLITRK6 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- STX1A participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- STXBP1 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- SYT1 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- SYT10 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- SYT12 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- SYT2 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- SYT7 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only
- SYT9 participates in Protein-protein interactions at synapsesProteinReactome R-HSA-6794362Inferred only