Pathway
Unblocking of NMDA receptors, glutamate binding and activation
At resting membrane potential, the NMDA receptor ion channel is blocked by extracellular Mg2+ ions and is unable to mediate ion permeation upon binding of ligands (glutamate, glycine, D-serine, NMDA). The voltage block is removed upon depolarization of the post-synaptic cell membrane and Mg2+ is expelled from the NMDA receptor pore (channel), resulting in activated ligand-bound NMDA receptors. The depolarization of the membrane may happen in response to activation of Ca2+ impermeable AMPA receptors, which facilitates Na+ influx, contributing to the unblocking of NMDA receptors. For review, please refer to Traynelis et al. 2010, Paoletti et al. 2013, and Iacobucci and Popescu 2017.
What the reference databases state
Statements
21 statements
21 statements · 1 reference database · Subject: Unblocking of NMDA receptors, glutamate binding and activation · Sources: Reactome
- ACTN2 participates in Unblocking of NMDA receptors, glutamate binding and activationProteinReactome R-HSA-438066Inferred only
- CALM1 participates in Unblocking of NMDA receptors, glutamate binding and activationProteinReactome R-HSA-438066Inferred only
- CAMK2A participates in Unblocking of NMDA receptors, glutamate binding and activationProteinReactome R-HSA-438066Inferred only
- CAMK2B participates in Unblocking of NMDA receptors, glutamate binding and activationProteinReactome R-HSA-438066Inferred only
- CAMK2D participates in Unblocking of NMDA receptors, glutamate binding and activationProteinReactome R-HSA-438066Inferred only
- CAMK2G participates in Unblocking of NMDA receptors, glutamate binding and activationProteinReactome R-HSA-438066Inferred only
- DLG1 participates in Unblocking of NMDA receptors, glutamate binding and activationProteinReactome R-HSA-438066Inferred only
- DLG2 participates in Unblocking of NMDA receptors, glutamate binding and activationProteinReactome R-HSA-438066Inferred only
- DLG3 participates in Unblocking of NMDA receptors, glutamate binding and activationProteinReactome R-HSA-438066Inferred only
- DLG4 participates in Unblocking of NMDA receptors, glutamate binding and activationProteinReactome R-HSA-438066Inferred only
- GRIA1 participates in Unblocking of NMDA receptors, glutamate binding and activationProteinReactome R-HSA-438066Inferred only
- GRIA2 participates in Unblocking of NMDA receptors, glutamate binding and activationProteinReactome R-HSA-438066Inferred only
Show the remaining 9
- GRIA3 participates in Unblocking of NMDA receptors, glutamate binding and activationProteinReactome R-HSA-438066Inferred only
- GRIA4 participates in Unblocking of NMDA receptors, glutamate binding and activationProteinReactome R-HSA-438066Inferred only
- GRIN1 participates in Unblocking of NMDA receptors, glutamate binding and activationProteinReactome R-HSA-438066Inferred only
- GRIN2A participates in Unblocking of NMDA receptors, glutamate binding and activationProteinReactome R-HSA-438066Inferred only
- GRIN2B participates in Unblocking of NMDA receptors, glutamate binding and activationProteinReactome R-HSA-438066Inferred only
- GRIN2C participates in Unblocking of NMDA receptors, glutamate binding and activationProteinReactome R-HSA-438066Inferred only
- GRIN2D participates in Unblocking of NMDA receptors, glutamate binding and activationProteinReactome R-HSA-438066Inferred only
- LRRC7 participates in Unblocking of NMDA receptors, glutamate binding and activationProteinReactome R-HSA-438066Inferred only
- NEFL participates in Unblocking of NMDA receptors, glutamate binding and activationProteinReactome R-HSA-438066Inferred only