Loading the page.
Proteins/UNIPROT:P15328
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation (By similarity)..
Function from UniProtKB (P15328), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
1 row
40 statements
40 statements · 5 reference databases · Subject: FOLR1 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, WikiPathways
3 reactions
5-methyltetrahydrofolic acid5-methyltetrahydrofolic acid
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR03916CC BY 4.0Reference data
Transported by FOLR1 or FOLR3 or FOLR2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05007CC BY 4.0Reference data
8 names
Resolves to: FOLR1
(6R)-5,10-methylenetetrahydrofolic acid(6R)-5,10-methylenetetrahydrofolic acid
Transported by FOLR1 or FOLR3 or FOLR2
Reaction pageLeft to rightBalancedEC 7.6.2.2extracellular space, cytosol
Human-GEM MAR11800CC BY 4.0Reference data