Proteins/UNIPROT:P53609

PGGT1B

ProteinUNIPROT:P53609

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B..

Function from UniProtKB (P53609), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

13 statements

13 statements · 3 reference databases · Subject: PGGT1B · Sources: Hetionet, Reactome, UniProt

Order

PGGT1B covaries with DUS1LProteinHetionet hetionet:covaries:5229-64118Inferred only
CDC42 interacts with PGGT1BProteinHetionet hetionet:interacts:5229-998Inferred only
KRAS interacts with PGGT1BProteinHetionet hetionet:interacts:3845-5229Inferred only
RHOB interacts with PGGT1BProteinHetionet hetionet:interacts:388-5229Inferred only
PGGT1B interacts with RRAS2ProteinHetionet hetionet:interacts:22800-5229Inferred only
PGGT1B interacts with UBCProteinHetionet hetionet:interacts:5229-7316Inferred only
PGGT1B participates in Antimicrobial mechanism of IFN-stimulated genesPathwayReactome R-HSA-1169410Inferred only
PGGT1B participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only
PGGT1B participates in GBP-mediated host defensePathwayReactome R-HSA-9953170Inferred only
PGGT1B participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
PGGT1B participates in Interferon SignalingPathwayReactome R-HSA-913531Inferred only
PGGT1B requires the cofactor magnesium(2+)CompoundUniProt P53609Inferred only

Show the remaining 1

PGGT1B requires the cofactor Zn(2+)CompoundUniProt P53609Inferred only

Reactions

1 reaction

CHEBI:57533+L-cysteinyl-[protein]S-geranylgeranyl-L-cysteinyl-[protein]+diphosphate(3-)
Catalysed by FNTA or PGGT1B or RABGGTB or RABGGTA
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:21240CC BY 4.0Reference data

Other names

3 names

Resolves to: PGGT1B

Also called: Geranylgeranyl transferase type I subunit betaGGTase-I-betaType I protein geranyl-geranyltransferase subunit beta

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