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Papers/PMID:17157199

Ascorbate inhibits NADPH oxidase subunit p47phox expression in microvascular endothelial cells.

Free radical biology & medicine2007The record

1 finding · 1 compound · 1 endpoint

L-ascorbic acid

What it reported

How to read these marks

What moved

1 finding

L-ascorbic acid — inhibits FMO5
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding
“In conclusion, ascorbate blocks the stimulation by septic insult of redox-sensitive Jak2/Stat1/IRF1 signaling, p47phox expression, and NADPH oxidase activity in microvascular endothelial cells.”
Quoted verbatim from Ascorbate inhibits NADPH oxidase subunit p47phox expression in microvascular endothelial cells..
Study

in vitro · not in humans
Population

mouse microvascular endothelial cells of skeletal muscle origin exposed to lipopolysaccharide and interferon-gamma
Ascorbate inhibits NADPH oxidase subunit p47phox expression in microvascular endothelial cells.2007PMID:17157199Permalink