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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:P31512

FMO4

Protein·UNIPROT:P31512

Open in the graph

Is likely involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Is able to use methimazole as substrate..

Function from UniProtKB (P31512), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

7 statements

7 statements · 4 reference databases · Subject: FMO4 · Sources: Hetionet, Human-GEM, UniProt, WikiPathways

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CDK5R2 covaries with FMO4ProteinHetionet hetionet:covaries:2329-8941Inferred only
XRCC6 covaries with FMO4ProteinHetionet hetionet:covaries:2329-2547Inferred only
selenomethionine is metabolised by FMO4CompoundHuman-GEM MAR04009Inferred only
selenomethionine is metabolised by FMO4CompoundHuman-GEM MAR07138Inferred only
FMO4 participates in Catalytic cycle of mammalian flavin containing monooxygenases FMOs PathwayWikiPathways WP688Inferred only
FMO4 participates in Metapathway biotransformation Phase I and IIPathwayWikiPathways WP702Inferred only
FMO4 requires the cofactor FAD(3-)CompoundUniProt P31512Inferred only

Reactions

4 reactions

proton+NADPH(4-)+dioxygen+selenomethioninewater+NADP(3-)+MAM02892r
Catalysed by FMO3 or FMO1 or FMO4 or FMO2 or FMO5
Reaction pageLeft to rightBalancedEC 1.14.13.8endoplasmic reticulum
Human-GEM MAR04009CC BY 4.0Reference data
proton+

Other names

3 names

Resolves to: FMO4

Also called: FMO 4FMO2Hepatic flavin-containing monooxygenase 4

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+selenomethionine

→

+MAM02892c

Catalysed by FMO3 or FMO1 or FMO4 or FMO2 or FMO5

Reaction pageLeft to rightBalancedEC 1.14.13.8cytosol

Human-GEM MAR07138CC BY 4.0Reference data

NADPH(4-)+dioxygen+MAM03053cwater+NADP(3-)+MAM03054c

Catalysed by FMO3 or FMO1 or FMO4 or FMO2 or FMO5

Reaction pageLeft to rightBalancedEC 1.14.13.8cytosol

Human-GEM MAR09514CC BY 4.0Reference data

CHEBI:16269+NADPH(4-)+dioxygen+hydronCHEBI:17735+NADP(3-)+water

Catalysed by FMO4 or FMO3 or FMO5 or FMO1

Reaction pageLeft to rightBalanced

Rhea RHEA:24468CC BY 4.0Reference data