Pathway
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
The epoxidation of arachidonate by cytochrome P450s (CYPs) results in the formation of unique bioactive lipid mediators termed epoxyeicosatrienoates (EETs). Each double bond has been shown to be susceptible to oxidation, resulting in 5,6-EET, 8,9-EET, 11,12-EET, and 14,15-EET. The majority of the EET biological activities are diminished by the hydrolysis to the corresponding dihydroxyeicosatrienoates (DHET).
REACT:R-HSA-2142670Reactome
What the reference databases state
Statements
8 statements
8 statements · 1 reference database · Subject: Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) · Sources: Reactome
- CYP1A1 participates in Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)ProteinReactome R-HSA-2142670Inferred only
- CYP1A2 participates in Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)ProteinReactome R-HSA-2142670Inferred only
- CYP1B1 participates in Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)ProteinReactome R-HSA-2142670Inferred only
- CYP2C19 participates in Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)ProteinReactome R-HSA-2142670Inferred only
- CYP2C8 participates in Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)ProteinReactome R-HSA-2142670Inferred only
- CYP2C9 participates in Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)ProteinReactome R-HSA-2142670Inferred only
- CYP2J2 participates in Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)ProteinReactome R-HSA-2142670Inferred only
- EPHX2 participates in Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)ProteinReactome R-HSA-2142670Inferred only