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Proteins/UNIPROT:P56178
Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding..
Function from UniProtKB (P56178), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
52 statements
52 statements · 4 reference databases · Subject: DLX5 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
1 name
Resolves to: DLX5