Proteins/UNIPROT:P57073

SOX8

ProteinUNIPROT:P57073

Transcription factor that may play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3' (By similarity)..

Function from UniProtKB (P57073), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

36 statements

36 statements · 3 reference databases · Subject: SOX8 · Sources: gene ontology, Hetionet, WikiPathways

Order

BAIAP2L2 covaries with SOX8ProteinHetionet hetionet:covaries:30812-80115Inferred only
CACNA1H covaries with SOX8ProteinHetionet hetionet:covaries:30812-8912Inferred only
CEBPA interacts with SOX8ProteinHetionet hetionet:interacts:1050-30812Inferred only
DLX5 interacts with SOX8ProteinHetionet hetionet:interacts:1749-30812Inferred only
EGR2 interacts with SOX8ProteinHetionet hetionet:interacts:1959-30812Inferred only
HHEX interacts with SOX8ProteinHetionet hetionet:interacts:30812-3087Inferred only
HOXC11 interacts with SOX8ProteinHetionet hetionet:interacts:30812-3227Inferred only
SOX8 interacts with JAM2ProteinHetionet hetionet:interacts:30812-58494Inferred only
JUN interacts with SOX8ProteinHetionet hetionet:interacts:30812-3725Inferred only
MMP1 interacts with SOX8ProteinHetionet hetionet:interacts:30812-4312Inferred only
NOD1 interacts with SOX8ProteinHetionet hetionet:interacts:10392-30812Inferred only
OLIG2 interacts with SOX8ProteinHetionet hetionet:interacts:10215-30812Inferred only

Show the remaining 24

PAX3 interacts with SOX8ProteinHetionet hetionet:interacts:30812-5077Inferred only
SOX8 interacts with PIDD1ProteinHetionet hetionet:interacts:30812-55367Inferred only
POU3F3 interacts with SOX8ProteinHetionet hetionet:interacts:30812-5455Inferred only
SP1 interacts with SOX8ProteinHetionet hetionet:interacts:30812-6667Inferred only
TCF12 interacts with SOX8ProteinHetionet hetionet:interacts:30812-6938Inferred only
UBC interacts with SOX8ProteinHetionet hetionet:interacts:30812-7316Inferred only
UTF1 interacts with SOX8ProteinHetionet hetionet:interacts:30812-8433Inferred only
SOX8 participates in Mammalian disorder of sexual developmentPathwayWikiPathways WP4842Inferred only
SOX8 participates in Oligodendrocyte developmentPathwayWikiPathways WP5574Inferred only
SOX8 participates in Oligodendrocyte specification and differentiation leading to myelin components for CNSPathwayWikiPathways WP4304Inferred only
SOX8 participates in Pre implantation embryoPathwayWikiPathways WP3527Inferred only
SOX8 participates in Primary ovarian insufficiencyPathwayWikiPathways WP5461Inferred only
SOX8 participates in Somatic sex determinationPathwayWikiPathways WP4814Inferred only
SOX8 regulates negative regulation of apoptotic processBiological processgene ontology P57073|GO:0043066Inferred only
SOX8 regulates negative regulation of DNA-templated transcriptionBiological processgene ontology P57073|GO:0045892Inferred only
SOX8 regulates negative regulation of myoblast differentiationBiological processgene ontology P57073|GO:0045662Inferred only
SOX8 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology P57073|GO:0000122Inferred only
SOX8 regulates positive regulation of branching involved in ureteric bud morphogenesisBiological processgene ontology P57073|GO:0090190Inferred only
SOX8 regulates positive regulation of DNA-templated transcriptionBiological processgene ontology P57073|GO:0045893Inferred only
SOX8 regulates positive regulation of gliogenesisBiological processgene ontology P57073|GO:0014015Inferred only
SOX8 regulates positive regulation of kidney developmentBiological processgene ontology P57073|GO:0090184Inferred only
SOX8 regulates positive regulation of osteoblast proliferationBiological processgene ontology P57073|GO:0033690Inferred only
SOX8 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology P57073|GO:0045944Inferred only
SOX8 regulates regulation of hormone levelsBiological processgene ontology P57073|GO:0010817Inferred only

Other names

2 names

Resolves to: SOX8

Also called: SOX-8Transcription factor SOX-8

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