Loading the page.
Proteins/UNIPROT:Q9Y2Z9
FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-decaprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-decaprenyl)benzoic acid. Also acts downstream of COQ4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-decaprenyl)phenol to 2-methoxy-6-(all-trans-decaprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to COQ6 from NADPH via a ferredoxin/ferredoxin reductase system composed of FDX2 and FDXR..
Function from UniProtKB (Q9Y2Z9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
36 statements
36 statements · 6 reference databases · Subject: COQ6 · Sources: Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
17 reactions
2-methoxy-6-(all-trans-decaprenyl)phenol+dioxygenwater+MAM03173m
Catalysed by COQ6
Reaction pageLeft to rightBalancedEC 1.14.15.-mitochondrial matrix
Human-GEM MAR00133CC BY 4.0Reference data
calcidiol+proton+NADPH(4-)+dioxygenMAM00608c+water+NADP(3-)
Catalysed by COQ6
2 names
Resolves to: COQ6
Reaction pageLeft to rightBalancedEC 1.14.13.-cytosol
Human-GEM MAR02129CC BY 4.0Reference data
MAM00608m+water+NADP(3-)calcidiol+proton+NADPH(4-)+dioxygen
Catalysed by COQ6 or CYP2E1 or CYP4V2
Reaction pageReversibleBalancedEC 1.14.13.-mitochondrial matrix
Human-GEM MAR02130CC BY 4.0Reference data
MAM00608c+proton+NADH(2-)+dioxygenMAM00607c+water+NAD(+)
Catalysed by COQ6 or CYP2E1 or CYP4V2
Reaction pageLeft to rightBalancedEC 1.14.13.-cytosol
Human-GEM MAR02131CC BY 4.0Reference data
MAM00608m+proton+NADH(2-)+dioxygenMAM00607m+water+NAD(+)
Catalysed by COQ6 or CYP2E1 or CYP4V2
Reaction pageLeft to rightBalancedEC 1.14.13.-mitochondrial matrix
Human-GEM MAR02132CC BY 4.0Reference data
MAM00607c+dioxygenMAM00621c+hydrogen peroxide
Catalysed by COQ6 or CYP2E1 or CYP4V2
Reaction pageLeft to rightBalancedEC 1.14.13.-cytosol
Human-GEM MAR02133CC BY 4.0Reference data
MAM00607m+dioxygenMAM00621m+hydrogen peroxide
Catalysed by COQ6 or CYP2E1 or CYP4V2
Reaction pageLeft to rightBalancedEC 1.14.13.-mitochondrial matrix
Human-GEM MAR02134CC BY 4.0Reference data
MAM00621c+dioxygenMAM00622c+hydrogen peroxide
Catalysed by COQ6 or CYP2E1 or CYP4V2
Reaction pageLeft to rightBalancedEC 1.14.13.-cytosol
Human-GEM MAR02135CC BY 4.0Reference data
MAM00621m+dioxygenMAM00622m+hydrogen peroxide
Catalysed by COQ6 or CYP2E1 or CYP4V2
Reaction pageLeft to rightBalancedEC 1.14.13.-mitochondrial matrix
Human-GEM MAR02136CC BY 4.0Reference data
calcitetrol+proton+NADPH(4-)+dioxygen(1S)-1,25-dihydroxy-24-oxocalciol+2water+NADP(3-)
Catalysed by COQ6 or CYP2E1 or CYP4V2
Reaction pageLeft to rightBalancedEC 1.14.13.-cytosol
Human-GEM MAR02142CC BY 4.0Reference data
calcitetrol+proton+NADPH(4-)+dioxygen(1S)-1,25-dihydroxy-24-oxocalciol+2water+NADP(3-)
Catalysed by COQ6 or CYP2E1 or CYP4V2
Reaction pageLeft to rightBalancedEC 1.14.13.-mitochondrial matrix
Human-GEM MAR02143CC BY 4.0Reference data
(1S)-1,25-dihydroxy-24-oxocalciol+proton+NADPH(4-)+dioxygenMAM00611c+water+NADP(3-)
Catalysed by COQ6 or CYP2E1 or CYP4V2
Reaction pageLeft to rightBalancedEC 1.14.13.-cytosol
Human-GEM MAR02144CC BY 4.0Reference data