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Proteins/UNIPROT:Q9Y275
Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response..
Isoform 2 seems to inhibit isoform 1 secretion and bioactivity..
[Isoform 3]: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis..
Function from UniProtKB (Q9Y275), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
53 statements
53 statements · 4 reference databases · Subject: TNFSF13B · Sources: gene ontology, Hetionet, Reactome, WikiPathways
11 names
Resolves to: TNFSF13B