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Proteins/UNIPROT:Q8NFA2

NOXO1

Protein·UNIPROT:Q8NFA2

Open in the graph

Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity..

Function from UniProtKB (Q8NFA2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

27 statements

27 statements · 4 reference databases · Subject: NOXO1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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NOXO1 covaries with ANO9ProteinHetionet hetionet:covaries:124056-338440Inferred only
BST2 covaries with NOXO1ProteinHetionet hetionet:covaries:124056-684Inferred only
NOXO1 covaries with DLEU7ProteinHetionet hetionet:covaries:124056-220107Inferred only
NOXO1 covaries with PLXNC1ProteinHetionet hetionet:covaries:10154-124056Inferred only
RASSF10 covaries with NOXO1ProteinHetionet hetionet:covaries:124056-644943Inferred only
NOXO1 covaries with SLC8B1ProteinHetionet hetionet:covaries:124056-80024Inferred only
TMEM139 covaries with NOXO1ProteinHetionet hetionet:covaries:124056-135932Inferred only
CYBA interacts with NOXO1ProteinHetionet hetionet:interacts:124056-1535Inferred only
NOXA1 interacts with NOXO1ProteinHetionet hetionet:interacts:10811-124056Inferred only
TGFBR1 interacts with NOXO1ProteinHetionet hetionet:interacts:124056-7046Inferred only
NOXO1 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
NOXO1 participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only

Show the remaining 15

NOXO1 participates in Killing mechanismsPathwayReactome R-HSA-9664420Inferred only
NOXO1 participates in Leishmania infectionPathwayReactome R-HSA-9658195Inferred only
NOXO1 participates in Parasitic Infection PathwaysPathwayReactome R-HSA-9824443Inferred only
NOXO1 participates in RAC1 GTPase cyclePathwayReactome R-HSA-9013149Inferred only
NOXO1 participates in RAC3 GTPase cyclePathwayReactome R-HSA-9013423Inferred only
NOXO1 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
NOXO1 participates in RHO GTPase EffectorsPathwayReactome R-HSA-195258Inferred only
NOXO1 participates in RHO GTPases Activate NADPH OxidasesPathwayReactome R-HSA-5668599Inferred only
NOXO1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
NOXO1 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
NOXO1 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
NOXO1 participates in TNF alpha signalingPathwayWikiPathways WP231Inferred only
NOXO1 participates in WNT5:FZD7-mediated leishmania dampingPathwayReactome R-HSA-9673324Inferred only
NOXO1 regulates regulation of hydrogen peroxide metabolic processBiological processgene ontology Q8NFA2|GO:0010310Inferred only
NOXO1 regulates regulation of respiratory burstBiological processgene ontology Q8NFA2|GO:0060263Inferred only

Other names

6 names

Resolves to: NOXO1

Also called: NADPH oxidase regulatory proteinNox organizer 1Nox-organizing protein 1P41NOXSH3 and PX domain-containing protein 5SH3PXD5

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