Proteins/UNIPROT:Q9BX26

SYCP2

ProteinUNIPROT:Q9BX26

Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. Plays a role in the assembly of synaptonemal complexes. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. Required for insertion of SYCP3 into synaptonemal complexes. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements..

Function from UniProtKB (Q9BX26), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

spermatogenic failure 1 has a germline basis in SYCP2DiseaseGenCC HGNC:11490|MONDO:0009776Inferred only

Statements

10 statements

10 statements · 2 reference databases · Subject: SYCP2 · Sources: Hetionet, Reactome

Order

DDX53 covaries with SYCP2ProteinHetionet hetionet:covaries:10388-168400Inferred only
SYCP2 covaries with HIRIP3ProteinHetionet hetionet:covaries:10388-8479Inferred only
SYCP2 covaries with LTO1ProteinHetionet hetionet:covaries:10388-220064Inferred only
TERB1 covaries with SYCP2ProteinHetionet hetionet:covaries:10388-283847Inferred only
TEX11 covaries with SYCP2ProteinHetionet hetionet:covaries:10388-56159Inferred only
SYCP2 participates in Cell CyclePathwayReactome R-HSA-1640170Inferred only
SYCP2 participates in MeiosisPathwayReactome R-HSA-1500620Inferred only
SYCP2 participates in Meiotic synapsisPathwayReactome R-HSA-1221632Inferred only
SYCP2 participates in ReproductionPathwayReactome R-HSA-1474165Inferred only
FOXJ3 increases the expression of SYCP2ProteinHetionet hetionet:regulates:22887-10388Inferred only

Other names

4 names

Resolves to: SYCP2

Also called: hsSCP2SCP-2SCP2Synaptonemal complex lateral element protein

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