Proteins/UNIPROT:Q9P2W1

PSMC3IP

ProteinUNIPROT:Q9P2W1

Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors..

Function from UniProtKB (Q9P2W1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

46 XX gonadal dysgenesis has a germline basis in PSMC3IPDiseaseGenCC HGNC:17928|MONDO:0009299Inferred only
ovarian dysgenesis 3 has a germline basis in PSMC3IPDiseaseGenCC HGNC:17928|MONDO:0013689Inferred only

Statements

17 statements

17 statements · 3 reference databases · Subject: PSMC3IP · Sources: Hetionet, Reactome, WikiPathways

Order

FAM171A2 covaries with PSMC3IPProteinHetionet hetionet:covaries:284069-29893Inferred only
NPB covaries with PSMC3IPProteinHetionet hetionet:covaries:256933-29893Inferred only
AR interacts with PSMC3IPProteinHetionet hetionet:interacts:29893-367Inferred only
ESR2 interacts with PSMC3IPProteinHetionet hetionet:interacts:2100-29893Inferred only
NR3C1 interacts with PSMC3IPProteinHetionet hetionet:interacts:2908-29893Inferred only
PSMC3 interacts with PSMC3IPProteinHetionet hetionet:interacts:29893-5702Inferred only
RXRA interacts with PSMC3IPProteinHetionet hetionet:interacts:29893-6256Inferred only
THRB interacts with PSMC3IPProteinHetionet hetionet:interacts:29893-7068Inferred only
PSMC3IP participates in Androgen receptor signalingPathwayWikiPathways WP138Inferred only
PSMC3IP participates in Cell CyclePathwayReactome R-HSA-1640170Inferred only
PSMC3IP participates in MeiosisPathwayReactome R-HSA-1500620Inferred only
PSMC3IP participates in Meiotic recombinationPathwayReactome R-HSA-912446Inferred only

Show the remaining 5

PSMC3IP participates in Primary ovarian insufficiencyPathwayWikiPathways WP5461Inferred only
PSMC3IP participates in ReproductionPathwayReactome R-HSA-1474165Inferred only
CASP3 decreases the expression of PSMC3IPProteinHetionet hetionet:regulates:836-29893Inferred only
KHDRBS1 increases the expression of PSMC3IPProteinHetionet hetionet:regulates:10657-29893Inferred only
WFS1 decreases the expression of PSMC3IPProteinHetionet hetionet:regulates:7466-29893Inferred only

Other names

7 names

Resolves to: PSMC3IP

Also called: HOP2Nuclear receptor coactivator GT198Proteasome 26S ATPase subunit 3-interacting proteinPSMC3-interacting proteinTat-binding protein 1-interacting proteinTBP-1-interacting proteinTBPIP

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