Proteins/UNIPROT:Q8IZU3

SYCP3

ProteinUNIPROT:Q8IZU3

Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells (By similarity). Required for normal meiosis during spermatogenesis and male fertility. Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity)..

Function from UniProtKB (Q8IZU3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

infertility disorder has a germline basis in SYCP3DiseaseGenCC HGNC:18130|MONDO:0005047Inferred only

Statements

13 statements

13 statements · 2 reference databases · Subject: SYCP3 · Sources: Hetionet, Reactome

Order

COG1 covaries with SYCP3ProteinHetionet hetionet:covaries:50511-9382Inferred only
INHA covaries with SYCP3ProteinHetionet hetionet:covaries:3623-50511Inferred only
MAPK8IP3 covaries with SYCP3ProteinHetionet hetionet:covaries:23162-50511Inferred only
RHBDL1 covaries with SYCP3ProteinHetionet hetionet:covaries:50511-9028Inferred only
SYCP3 covaries with RPL22ProteinHetionet hetionet:covaries:50511-6146Inferred only
SEMA6D covaries with SYCP3ProteinHetionet hetionet:covaries:50511-80031Inferred only
WNT7B covaries with SYCP3ProteinHetionet hetionet:covaries:50511-7477Inferred only
LIG4 interacts with SYCP3ProteinHetionet hetionet:interacts:3981-50511Inferred only
PABPC1 interacts with SYCP3ProteinHetionet hetionet:interacts:26986-50511Inferred only
SYCP3 participates in Cell CyclePathwayReactome R-HSA-1640170Inferred only
SYCP3 participates in MeiosisPathwayReactome R-HSA-1500620Inferred only
SYCP3 participates in Meiotic synapsisPathwayReactome R-HSA-1221632Inferred only

Show the remaining 1

SYCP3 participates in ReproductionPathwayReactome R-HSA-1474165Inferred only

Other names

3 names

Resolves to: SYCP3

Also called: SCP-3SCP3Synaptonemal complex protein 3

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