Proteins/UNIPROT:O95072

REC8

ProteinUNIPROT:O95072

Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity)..

Function from UniProtKB (O95072), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

primary ovarian failure has a germline basis in REC8DiseaseGenCC HGNC:16879|MONDO:0005387Inferred only

Statements

7 statements

7 statements · 3 reference databases · Subject: REC8 · Sources: Hetionet, Reactome, WikiPathways

Order

ZYX covaries with REC8ProteinHetionet hetionet:covaries:7791-9985Inferred only
REC8 participates in Cell CyclePathwayReactome R-HSA-1640170Inferred only
REC8 participates in Cohesin complex Cornelia de Lange syndromePathwayWikiPathways WP5117Inferred only
REC8 participates in Male infertilityPathwayWikiPathways WP4673Inferred only
REC8 participates in MeiosisPathwayReactome R-HSA-1500620Inferred only
REC8 participates in Meiotic synapsisPathwayReactome R-HSA-1221632Inferred only
REC8 participates in ReproductionPathwayReactome R-HSA-1474165Inferred only

Other names

3 names

Resolves to: REC8

Also called: Cohesin Rec8pMeiotic recombination protein REC8 homologREC8L1

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