Catalyst

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Search ?

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

Reach

2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

73 compounds within 3 steps: 1 in 1, 5 in 2, 67 in 3

Does it reach a compound?

Three steps

(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
1. phosphatidate phosphatase (1-lyso-2-arachidonoyl-phosphatidate)
2. fatty acid amide hydrolase (2-arachidonoylglycerol)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
Catalysed by PLPP1, PLPP3, PLPP2, LPIN1 and 9 morecytosol
(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoateReach from here →
1. phosphatidate phosphatase (1-lyso-2-arachidonoyl-phosphatidate)
2. fatty acid amide hydrolase (2-arachidonoylglycerol)
3. Arachidonate:oxygen 8-oxidoreductase
Catalysed by PLPP1, PLPP3, PLPP2, LPIN1 and 9 morecytosolOne of 2 routes
1-(9Z,12Z,15Z-octadecatrienoyl)-glycerolReach from here →
1. phosphatidate phosphatase (1-lyso-2-arachidonoyl-phosphatidate)
2. 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
Catalysed by PLPP1, PLPP3, PLPP2, LPIN1 and 19 morecytosol
1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerolReach from here →
1. phosphatidate phosphatase (1-lyso-2-arachidonoyl-phosphatidate)
2. 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
Catalysed by PLPP1, PLPP3, PLPP2, LPIN1 and 19 morecytosol
2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerolReach from here →
1. phosphatidate phosphatase (1-lyso-2-arachidonoyl-phosphatidate)
2. fatty acid amide hydrolase (2-arachidonoylglycerol)
3. fatty acid amide hydrolase (arachidonate)
Catalysed by PLPP1, PLPP3, PLPP2, LPIN1 and 8 morecytosol
20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. phosphatidate phosphatase (1-lyso-2-arachidonoyl-phosphatidate)
2. fatty acid amide hydrolase (2-arachidonoylglycerol)
3. arachidonic acid:oxygen 1-oxidoreductase
Catalysed by PLPP1, PLPP3, PLPP2, LPIN1 and 35 morecytosolOne of 3 routes
11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →
1. phosphatidate phosphatase (1-lyso-2-arachidonoyl-phosphatidate)
2. fatty acid amide hydrolase (2-arachidonoylglycerol)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by PLPP1, PLPP3, PLPP2, LPIN1 and 9 morecytosol
19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. phosphatidate phosphatase (1-lyso-2-arachidonoyl-phosphatidate)
2. fatty acid amide hydrolase (2-arachidonoylglycerol)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by PLPP1, PLPP3, PLPP2, LPIN1 and 13 morecytosol
(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. phosphatidate phosphatase (1-lyso-2-arachidonoyl-phosphatidate)
2. fatty acid amide hydrolase (2-arachidonoylglycerol)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by PLPP1, PLPP3, PLPP2, LPIN1 and 9 morecytosolOne of 2 routes
(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. phosphatidate phosphatase (1-lyso-2-arachidonoyl-phosphatidate)
2. fatty acid amide hydrolase (2-arachidonoylglycerol)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by PLPP1, PLPP3, PLPP2, LPIN1 and 9 morecytosolOne of 2 routes
(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. phosphatidate phosphatase (1-lyso-2-arachidonoyl-phosphatidate)
2. fatty acid amide hydrolase (2-arachidonoylglycerol)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
Catalysed by PLPP1, PLPP3, PLPP2, LPIN1 and 9 morecytosol
11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. phosphatidate phosphatase (1-lyso-2-arachidonoyl-phosphatidate)
2. fatty acid amide hydrolase (2-arachidonoylglycerol)
3. Arachidonate: oxygen 11-oxidoreductase
Catalysed by PLPP1, PLPP3, PLPP2, LPIN1 and 9 morecytosolOne of 2 routes
prostaglandin G2Reach from here →
1. phosphatidate phosphatase (1-lyso-2-arachidonoyl-phosphatidate)
2. fatty acid amide hydrolase (2-arachidonoylglycerol)
3. Arachidonate:oxygen oxidoreductase
Catalysed by PLPP1, PLPP3, PLPP2, LPIN1 and 10 morecytosol, endoplasmic reticulumOne of 2 routes
(12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
1. phosphatidate phosphatase (1-lyso-2-arachidonoyl-phosphatidate)
2. fatty acid amide hydrolase (2-arachidonoylglycerol)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by PLPP1, PLPP3, PLPP2, LPIN1 and 9 morecytosol
14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →
1. phosphatidate phosphatase (1-lyso-2-arachidonoyl-phosphatidate)
2. fatty acid amide hydrolase (2-arachidonoylglycerol)
3. unspecific monooxygenase (arachidonate)
Catalysed by PLPP1, PLPP3, PLPP2, LPIN1 and 35 morecytosolOne of 4 routes
8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →
1. phosphatidate phosphatase (1-lyso-2-arachidonoyl-phosphatidate)
2. fatty acid amide hydrolase (2-arachidonoylglycerol)
3. unspecific monooxygenase (arachidonate)
Catalysed by PLPP1, PLPP3, PLPP2, LPIN1 and 34 morecytosolOne of 3 routes
1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserineReach from here →
1. phosphatidate phosphatase (1-lyso-2-arachidonoyl-phosphatidate)
2. fatty acid amide hydrolase (2-arachidonoylglycerol)
3. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphoserine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
Catalysed by PLPP1, PLPP3, PLPP2, LPIN1 and 9 morecytosol
1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholineReach from here →
1. phosphatidate phosphatase (1-lyso-2-arachidonoyl-phosphatidate)
2. fatty acid amide hydrolase (2-arachidonoylglycerol)
3. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
Catalysed by PLPP1, PLPP3, PLPP2, LPIN1 and 9 morecytosol
1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
1. phosphatidate phosphatase (1-lyso-2-arachidonoyl-phosphatidate)
2. fatty acid amide hydrolase (2-arachidonoylglycerol)
3. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
Catalysed by PLPP1, PLPP3, PLPP2, LPIN1 and 9 morecytosol
2-glyceryl-prostaglandin H2Reach from here →
1. phosphatidate phosphatase (1-lyso-2-arachidonoyl-phosphatidate)
2. 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 2 O2 = 2-glyceryl-prostaglandin G2
3. 2-glyceryl-prostaglandin G2 + AH2 = 2-glyceryl-prostaglandin H2 + A + H2O
Catalysed by PLPP1, PLPP3, PLPP2, LPIN1 and 8 morecytosol
(18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. phosphatidate phosphatase (1-lyso-2-arachidonoyl-phosphatidate)
2. fatty acid amide hydrolase (2-arachidonoylglycerol)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by PLPP1, PLPP3, PLPP2, LPIN1 and 9 morecytosol
15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. phosphatidate phosphatase (1-lyso-2-arachidonoyl-phosphatidate)
2. fatty acid amide hydrolase (2-arachidonoylglycerol)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
Catalysed by PLPP1, PLPP3, PLPP2, LPIN1 and 9 morecytosol
5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. phosphatidate phosphatase (1-lyso-2-arachidonoyl-phosphatidate)
2. fatty acid amide hydrolase (2-arachidonoylglycerol)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate
Catalysed by PLPP1, PLPP3, PLPP2, LPIN1 and 9 morecytosol

Page 2 of 2