(13S)-hydroperoxy-(9Z,11E)-octadecadienoate

Three steps

• (R)-noradrenalineReach from here →
  1. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and noradrenaline (cytosol to extracellular)

  Catalysed by GPX1, GSTA1, GPX2, GPX4 and 8 morecytosol, extracellular spaceOne of 2 routes

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2

  Catalysed by GPX1, GSTA1, GPX2, GPX4 and 7 morecytosol, extracellular spaceOne of 2 routes

• (9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
  1. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by GPX1, GSTA1, GPX2, GPX4 and 1 more

• ursodeoxycholateReach from here →
  1. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and ursodeoxycholate (cytosol to extracellular)

  Catalysed by GPX1, GSTA1, GPX2, GPX4 and 8 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin G2Reach from here →
  1. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and prostaglandin G2 (cytosol to extracellular)

  Catalysed by GPX1, GSTA1, GPX2, GPX4 and 7 morecytosol, extracellular spaceOne of 2 routes

• glycodeoxycholateReach from here →
  1. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by GPX1, GSTA1, GPX2, GPX4 and 2 moreinner side of the membrane, outer side of the membrane

• (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by GPX1, GSTA1, GPX2, GPX4 and 1 more

• (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by GPX1, GSTA1, GPX2, GPX4 and 4 more

• (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by GPX1, GSTA1, GPX2, GPX4 and 1 more

• thromboxane B2Reach from here →
  1. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and thromboxane B2 (cytosol to extracellular)

  Catalysed by GPX1, GSTA1, GPX2, GPX4 and 7 morecytosol, extracellular spaceOne of 2 routes

• an S-substituted glutathioneReach from here →
  1. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by GPX1, GSTA1, GPX2, GPX4 and 23 moreOne of 2 routes

• taurochenodeoxycholateReach from here →
  1. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. solute carrier organic anion transporter (GSH)

  Catalysed by GPX1, GSTA1, GPX2, GPX4 and 9 morecytosol, extracellular spaceOne of 3 routes