(3S)-3-hydroxy-3-methylglutaryl-CoA

Three steps

• 17beta-estradiol 17-O-(beta-D-glucuronate)Reach from here →
  1. 3-hydroxy-3-methylglutarate + succinyl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + succinate
  2. 3-hydroxy-3-methylglutarate + glutaryl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + glutarate
  3. 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)

  Catalysed by SUGCT, SLC22A24inner side of the membrane, outer side of the membraneOne of 2 routes

• (5Z)-tetradecenoyl-CoAReach from here →
  1. 3-hydroxy-3-methylglutarate + glutaryl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + glutarate
  2. Production of Glutaryl Carnitine
  3. long-chain-fatty-acid-CoA ligase (physeteric acid)

  Catalysed by SUGCT, CPT1A, CPT1C, CPT1B and 8 morecytosolOne of 8 routes

• (3E)-decenoyl-CoAReach from here →
  1. 3-hydroxy-3-methylglutarate + glutaryl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + glutarate
  2. Production of Glutaryl Carnitine
  3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by SUGCT, CPT1A, CPT1C, CPT1B and 4 morecytosol, mitochondrial matrix

• O-3-oxobutanoyl-(R)-carnitineReach from here →
  1. 3-hydroxy-3-methylglutarate + succinyl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + succinate
  2. acetoacetate + succinyl-CoA = acetoacetyl-CoA + succinate
  3. acetoacetyl-CoA + (R)-carnitine = O-3-oxobutanoyl-(R)-carnitine + CoA

  Catalysed by SUGCT, OXCT1, CRAT

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. 3-hydroxy-3-methylglutarate + glutaryl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + glutarate
  2. Production of Glutaryl Carnitine
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by SUGCT, CPT1A, CPT1C, CPT1B and 3 morecytosol, mitochondrial matrix

• (7Z)-hexadecenoyl-CoAReach from here →
  1. 3-hydroxy-3-methylglutarate + glutaryl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + glutarate
  2. Production of Glutaryl Carnitine
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by SUGCT, CPT1A, CPT1C, CPT1B and 8 morecytosolOne of 8 routes

• tricosanoyl-CoAReach from here →
  1. 3-hydroxy-3-methylglutarate + glutaryl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + glutarate
  2. Production of Glutaryl Carnitine
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by SUGCT, CPT1A, CPT1C, CPT1B and 8 morecytosolOne of 4 routes

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. (3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA
  2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by HMGCL, HMGCLL1, PDHA1, PDHB and 1 moremitochondrial matrix, cytosol