diiodine

Three steps

• beta-alanineReach from here →
  1. thyroid peroxidase (iodine)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. transport of beta-alanine and chloride (cytosol to extracellular)

  Catalysed by TPO, SLC26A4, SLC6A6, SLC6A14cytosol, extracellular spaceOne of 2 routes

• L-alanineReach from here →
  1. thyroid peroxidase (iodine)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. transport of alanine and chloride (cytosol to extracellular)

  Catalysed by TPO, SLC26A4, SLC6A14cytosol, extracellular spaceOne of 2 routes

• L-asparagineReach from here →
  1. thyroid peroxidase (iodine)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. Transport of L-Asparagine by Atb0 Transporter

  Catalysed by TPO, SLC26A4, SLC6A14cytosol, extracellular spaceOne of 2 routes

• L-phenylalanineReach from here →
  1. thyroid peroxidase (iodine)
  2. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine

  Catalysed by TPO, IYD, PAHcytosolOne of 3 routes

• (6R)-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. thyroid peroxidase (iodine)
  2. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine

  Catalysed by TPO, IYD, PAHcytosol

• 4-aminobutanoateReach from here →
  1. thyroid peroxidase (iodine)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by TPO, SLC26A4, SLC6A12cytosol, extracellular spaceOne of 4 routes