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xylitol

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

13 compounds within 3 steps: 2 in 1, 4 in 2, 7 in 3

Does it reach a compound?

One step

D-xyluloseReach from here →
1. xylitol + NAD(+) = D-xylulose + NADH + H(+)
Catalysed by SORD
D-xyloseReach from here →
1. xylitol + NADP(+) = D-xylose + NADPH + H(+)
Catalysed by AKR1B1

Two steps

D-xylono-1,5-lactoneReach from here →
1. xylitol + NADP(+) = D-xylose + NADPH + H(+)
2. D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)
Catalysed by AKR1B1, DHDH
CHEBI:16332Reach from here →
1. xylitol + NAD(+) = D-xylulose + NADH + H(+)
2. ATP:D-xylulose 5-phosphotransferase
Catalysed by SORD, XYLBcytosol
D-xylulose 5-phosphateReach from here →

Three steps

keto-D-fructose 6-phosphateReach from here →
Catalysed by SORD, XYLB, TKT, TKTL1 and 1 morecytosol
CHEBI:16108Reach from here →
Catalysed by and 1 more

xylitol + NAD(+) = D-xylulose + NADH + H(+)

D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H(+)

Catalysed by SORD, XYLB

D-ribulose 1-phosphateReach from here →

xylitol + NAD(+) = D-xylulose + NADH + H(+)
ketohexokinase (D-xylulose)

Catalysed by SORD, KHKcytosol

cytosol

glycolaldehydeReach from here →

xylitol + NAD(+) = D-xylulose + NADH + H(+)
ketohexokinase (D-xylulose)
L-xylulose 1-phosphate glycolaldehyde-lyase (glycerone-phosphate-forming)

Catalysed by SORD, KHK, ALDOA, ALDOB and 1 morecytosol

CHEBI:29052Reach from here →

xylitol + NAD(+) = D-xylulose + NADH + H(+)
ATP:D-xylulose 5-phosphotransferase
D-Fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase

Catalysed by SORD, XYLB, TKT, TKTL1 and 1 morecytosolOne of 2 routes

D-sedoheptulose 7-phosphateReach from here →

xylitol + NAD(+) = D-xylulose + NADH + H(+)
ATP:D-xylulose 5-phosphotransferase
transketolase (D-xylulose-5-phosphate)

Catalysed by SORD, XYLB, TKT, TKTL1 and 1 morecytosolOne of 2 routes

D-ribulose 5-phosphateReach from here →

xylitol + NAD(+) = D-xylulose + NADH + H(+)
ATP:D-xylulose 5-phosphotransferase
D-Ribulose-5-phosphate 3-epimerase

Catalysed by SORD, XYLB, RPEL1, RPEcytosolOne of 2 routes

D-glyceraldehyde 3-phosphateReach from here →

xylitol + NAD(+) = D-xylulose + NADH + H(+)
D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H(+)
D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate

Catalysed by SORD, XYLB, TKT, TKTL1 and 1 more