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Proteins/UNIPROT:Q9UQ10
Catalyzes the NADP(+)-linked oxidation of trans-dihydrodiols of aromatic hydrocarbons to the corresponding catechols. It also catalyzes the oxidation of several pentoses and hexoses. In the reverse reaction in the presence of NADPH, it acts as NADPH-linked reductase on a broad range of substrates including aldehydes, chetones, and alpha-dicarbonyl compounds such as 3-deoxyglucosone, camphorquinone and methylglyoxal..
Function from UniProtKB (Q9UQ10), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
15 statements
15 statements · 3 reference databases · Subject: DHDH · Sources: Hetionet, Rhea, WikiPathways
9 reactions
MAM01758c+NADP(3-)D-xylono-1,5-lactone+proton+NADPH(4-)
Catalysed by DHDH
Reaction pageLeft to rightBalancedEC 1.1.1.179cytosol
Human-GEM MAR04594CC BY 4.0Reference data
9 names
Resolves to: DHDH
Reaction pageLeft to rightBalancedEC 1.3.1.20cytosol
Human-GEM MAR07005CC BY 4.0Reference data
MAM00932c+proton+NADPH(4-)MAM00929c+NADP(3-)
Catalysed by DHDH or AKR1C2 or CBR1 or CBR3 or AKR1C1 or AKR1C3 or AKR1C4
Reaction pageLeft to rightBalancedEC 1.1.1.146, 1.1.1.184, 1.3.1.20cytosol
Human-GEM MAR07059CC BY 4.0Reference data
D-ribose+NADP(3-)+waterCHEBI:17773+NADPH(4-)+2hydron
Catalysed by DHDH
Reaction pageDirection not assertedBalanced
Rhea RHEA:11676CC BY 4.0Reference data
D-glucose+NADP(3-)D-glucono-1,5-lactone+NADPH(4-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:14405CC BY 4.0Reference data
CHEBI:10702+NADP(3-)CHEBI:18135+NADPH(4-)+hydron
Catalysed by AKR1C2 or AKR1C1 or DHDH
Reaction pageDirection not assertedBalanced
Rhea RHEA:16729CC BY 4.0Reference data
D-galactose+NADP(3-)D-galactono-1,5-lactone+NADPH(4-)+hydron
Catalysed by DHDH
Reaction pageDirection not assertedBalanced
Rhea RHEA:18625CC BY 4.0Reference data
D-xylose+NADP(3-)D-xylono-1,5-lactone+NADPH(4-)+hydron
Catalysed by DHDH
Reaction pageDirection not assertedBalanced
Rhea RHEA:22000CC BY 4.0Reference data
CHEBI:46994+NADP(3-)CHEBI:194242+NADPH(4-)+hydron
Catalysed by DHDH
Reaction pageDirection not assertedBalanced
Rhea RHEA:75267CC BY 4.0Reference data