creatine

Three steps

• N(5)-[(Z)-amino(hydroxyimino)methyl]ornithineReach from here →
  1. S-Adenosyl-L-methionine:guanidinoacetate N-methyltransferase
  2. L-Arginine:glycine amidinotransferase
  3. L-arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)

  Catalysed by GAMT, GATM, NOS3, NOS1 and 1 morecytosol

• (2S)-2-aminobutanoateReach from here →
  1. S-Adenosyl-L-methionine:guanidinoacetate N-methyltransferase
  2. L-Arginine:glycine amidinotransferase
  3. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine

  Catalysed by GAMT, GATM, AGXT2cytosol

• glycodeoxycholateReach from here →
  1. S-Adenosyl-L-methionine:guanidinoacetate N-methyltransferase
  2. L-Arginine:glycine amidinotransferase
  3. Glycodeoxycholate amidohydrolase

  Catalysed by GAMT, GATMcytosolOne of 2 routes

• N-tetradecanoylglycineReach from here →
  1. S-Adenosyl-L-methionine:guanidinoacetate N-methyltransferase
  2. L-Arginine:glycine amidinotransferase
  3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

  Catalysed by GAMT, GATM, GLYATL2cytosol

• N-eicosanoylglycinateReach from here →
  1. S-Adenosyl-L-methionine:guanidinoacetate N-methyltransferase
  2. L-Arginine:glycine amidinotransferase
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by GAMT, GATM, BAATcytosol

• N-docosanoylglycineReach from here →
  1. S-Adenosyl-L-methionine:guanidinoacetate N-methyltransferase
  2. L-Arginine:glycine amidinotransferase
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by GAMT, GATM, BAATcytosol

• N-hexacosanoylglycineReach from here →
  1. S-Adenosyl-L-methionine:guanidinoacetate N-methyltransferase
  2. L-Arginine:glycine amidinotransferase
  3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

  Catalysed by GAMT, GATM, BAATcytosol