2-methyl-3-oxopropanoic acid
362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API
302 compounds within 3 steps: 5 in 1, 46 in 2, 251 in 3
Three steps
- aldehyde dehydrogenase (2-methyl-3-oxopropanoate)
- (R)-methylmalonyl-CoA = succinyl-CoA
- a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
Catalysed by ALDH6A1, MMUT, OXCT1, OXCT2mitochondrial matrix
- (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
- pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
- 2-(alpha-hydroxyethyl)thiamine-diphosphate[m] + lipoamide[m] = S-acetyldihydrolipoamide[m] + thiamin-PP[m]
Catalysed by AGXT2, PDHA1, PDHB, PDHA2 and 1 moremitochondrial matrix