CHEBI:15380

Three steps

• N-docosanoylglycineReach from here →
  1. 5-aminolevulinate synthase (2-amino-3-oxoadipate)
  2. long-chain-fatty-acid-CoA ligase (behenic acid)
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by ALAS1, CPNE7, SLC27A2, ACSL4 and 7 moremitochondrial matrix, cytosolOne of 2 routes

• N-hexacosanoylglycineReach from here →
  1. 5-aminolevulinate synthase (2-amino-3-oxoadipate)
  2. long-chain-fatty-acid-CoA ligase (cerotic acid)
  3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

  Catalysed by ALAS1, CPNE7, SLC27A2, ACSL4 and 7 moremitochondrial matrix, cytosolOne of 2 routes

• an N(2)-acyl-L-glutamineReach from here →
  1. 5-aminolevulinate synthase (2-amino-3-oxoadipate)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by ALAS1, CPNE7, ASAH1, ACER2 and 4 moremitochondrial matrix, Golgi apparatus

• (2E,5Z)-tetradecadienoyl-CoAReach from here →
  1. 5-aminolevulinate synthase (2-amino-3-oxoadipate)
  2. long-chain-fatty-acid-CoA ligase (physeteric acid)
  3. medium-chain acyl-CoA dehydrogenase (5-tetradecenoyl-CoA)

  Catalysed by ALAS1, CPNE7, SLC27A2, ACSL4 and 10 moremitochondrial matrix, cytosolOne of 4 routes

• (2E,7Z)-hexadecadienoyl-CoAReach from here →
  1. 5-aminolevulinate synthase (2-amino-3-oxoadipate)
  2. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)
  3. medium-chain acyl-CoA dehydrogenase (7-hexadecenoyl-CoA)

  Catalysed by ALAS1, CPNE7, SLC27A2, ACSL4 and 10 moremitochondrial matrix, cytosolOne of 4 routes

• cholesteryl (11Z)-octadecenoateReach from here →
  1. 5-aminolevulinate synthase (2-amino-3-oxoadipate)
  2. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix
  3. (11Z)-octadecenoyl-CoA + cholesterol = cholesteryl (11Z)-octadecenoate + CoA

  Catalysed by ALAS1, CPNE7, CPT1A, CPT1C and 2 moremitochondrial matrix, cytosol

• a 3-oxoacyl-CoAReach from here →
  1. 5-aminolevulinate synthase (2-amino-3-oxoadipate)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA

  Catalysed by ALAS1, CPNE7, ASAH1, ACER2 and 6 moremitochondrial matrix, Golgi apparatus

• taurochenodeoxycholateReach from here →
  1. 5-aminolevulinate synthase (2-amino-3-oxoadipate)
  2. Propanoyl-CoA:acetyl-CoA C-acyltransferase
  3. 3alpha,7alpha-dihydroxy-5beta-cholanoyl-CoA:taurine N-choloyltransferase

  Catalysed by ALAS1, CPNE7, ACAA1, SCP2 and 2 moremitochondrial matrix, peroxisomeOne of 5 routes