choline

Three steps

• (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoateReach from here →
  1. choline + A = betaine aldehyde + AH2
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O
  3. prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde

  Catalysed by CHDH, PTGS1, PTGS2, TBXAS1 and 2 more

• thromboxane B2Reach from here →
  1. Acetyl-CoA:choline O-acetyltransferase
  2. transport of acetylcholine (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by CHAT, SLCO1B3, SLCO1B1cytosol, extracellular spaceOne of 4 routes

• 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
  1. choline + A = betaine aldehyde + AH2
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O
  3. (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + NADH + H(+)

  Catalysed by CHDH, PTGS2, HPGD

• a 3-oxoacyl-CoAReach from here →
  1. Acetyl-CoA:choline O-acetyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA

  Catalysed by CHAT, ASAH1, ACER2, ACER1 and 5 morecytosol, Golgi apparatus

• 19-hydroxyprostaglandin H2Reach from here →
  1. choline + A = betaine aldehyde + AH2
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O
  3. prostaglandin H2 + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxyprostaglandin H2 + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by CHDH, PTGS1, PTGS2, CYP4F8

• 19-hydroxyprostaglandin H1Reach from here →
  1. choline + A = betaine aldehyde + AH2
  2. prostaglandin G1 + AH2 = prostaglandin H1 + A + H2O
  3. prostaglandin H1 + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxyprostaglandin H1 + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by CHDH, PTGS2, CYP4F8

• taurochenodeoxycholateReach from here →
  1. Acetyl-CoA:choline O-acetyltransferase
  2. transport of acetylcholine (cytosol to extracellular)
  3. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)

  Catalysed by CHAT, SLCO1B3, SLCO1A2, SLC7A9cytosol, extracellular spaceOne of 9 routes