17beta-hydroxy-androst-5-en-3-one

Three steps

• 4-hydroxy-17beta-estradiolReach from here →
  1. 17beta-hydroxy-androst-5-en-3-one = testosterone
  2. cytochrome P450 (testosterone)
  3. cytochrome P450 (estradiol-17beta)

  Catalysed by HSD3B1, CYP19A1, CYP3A4endoplasmic reticulum, cytosolOne of 3 routes

• 17beta-estradiol 17-O-(beta-D-glucuronate)Reach from here →
  1. 17beta-hydroxy-androst-5-en-3-one = testosterone
  2. cytochrome P450 (testosterone)
  3. 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + UDP + H(+)

  Catalysed by HSD3B1, CYP19A1, UGT2B17, UGT2A1 and 3 moreendoplasmic reticulum

• 6beta-hydroxyandrost-4-ene-3,17-dioneReach from here →
  1. 17beta-hydroxy-androst-5-en-3-one = testosterone
  2. testosterone + NAD(+) = androst-4-ene-3,17-dione + NADH + H(+)
  3. androst-4-ene-3,17-dione + reduced [NADPH--hemoprotein reductase] + O2 = 6beta-hydroxyandrost-4-ene-3,17-dione + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by HSD3B1, HSD17B6, AKR1C4, HSD17B2 and 5 more

• 16beta,17beta-estriolReach from here →
  1. 17beta-hydroxy-androst-5-en-3-one = testosterone
  2. cytochrome P450 (testosterone)
  3. 17beta-estradiol + reduced [NADPH--hemoprotein reductase] + O2 = 16beta,17beta-estriol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by HSD3B1, CYP19A1, CYP3A4endoplasmic reticulum