Proteins/UNIPROT:Q9UBN4

TRPC4

ProteinUNIPROT:Q9UBN4

Forms a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Forms a homomeric ion channel or a heteromeric ion channel with TRPC1; the heteromeric ion channel has reduced calcium permeability compared to the homomeric channel. Also permeable to monovalent ions including sodium, lithium and cesium ions..

[Isoform Beta]: Forms a receptor-activated non-selective calcium permeant cation channel..

Function from UniProtKB (Q9UBN4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

30 statements

30 statements · 5 reference databases · Subject: TRPC4 · Sources: gene ontology, Hetionet, Reactome, Rhea, WikiPathways

Order

TRPC4 covaries with FTSJ1ProteinHetionet hetionet:covaries:24140-7223Inferred only
TRPC4 covaries with PDLIM7ProteinHetionet hetionet:covaries:7223-9260Inferred only
TRPC4 covaries with PLCD1ProteinHetionet hetionet:covaries:5333-7223Inferred only
TRPC4 covaries with SOX18ProteinHetionet hetionet:covaries:54345-7223Inferred only
TRPC4 covaries with TRIM8ProteinHetionet hetionet:covaries:7223-81603Inferred only
TRPC4 interacts with ITCHProteinHetionet hetionet:interacts:7223-83737Inferred only
ITPR2 interacts with TRPC4ProteinHetionet hetionet:interacts:3709-7223Inferred only
ITPR3 interacts with TRPC4ProteinHetionet hetionet:interacts:3710-7223Inferred only
MX1 interacts with TRPC4ProteinHetionet hetionet:interacts:4599-7223Inferred only
TRPC4 interacts with NHERF1ProteinHetionet hetionet:interacts:7223-9368Inferred only
TJP1 interacts with TRPC4ProteinHetionet hetionet:interacts:7082-7223Inferred only
TRPC1 interacts with TRPC4ProteinHetionet hetionet:interacts:7220-7223Inferred only

Show the remaining 18

TRPC4 interacts with TRPC5ProteinHetionet hetionet:interacts:7223-7224Inferred only
TRPC4 interacts with UBCProteinHetionet hetionet:interacts:7223-7316Inferred only
TRPC4 participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
TRPC4 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
TRPC4 participates in Ion channel transportPathwayReactome R-HSA-983712Inferred only
TRPC4 participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
TRPC4 participates in Netrin-1 signalingPathwayReactome R-HSA-373752Inferred only
TRPC4 participates in Role of second messengers in netrin-1 signalingPathwayReactome R-HSA-418890Inferred only
TRPC4 participates in Stimuli-sensing channelsPathwayReactome R-HSA-2672351Inferred only
TRPC4 participates in Transport of small moleculesPathwayReactome R-HSA-382551Inferred only
TRPC4 participates in TRP channelsPathwayReactome R-HSA-3295583Inferred only
TRPC4 participates in Urotensin II mediated signalingPathwayWikiPathways WP5158Inferred only
TRPC4 regulates regulation of cytosolic calcium ion concentrationBiological processgene ontology Q9UBN4|GO:0051480Inferred only
TRPC4 regulates regulation of membrane depolarizationBiological processgene ontology Q9UBN4|GO:0003254Inferred only
Ca(2+) is transported by TRPC4CompoundRhea RHEA:29671Inferred only
Cs(+) is transported by TRPC4CompoundRhea RHEA:78555Inferred only
Li(+) is transported by TRPC4CompoundRhea RHEA:78551Inferred only
sodium(1+) is transported by TRPC4CompoundRhea RHEA:34963Inferred only

Reactions

4 reactions

Ca(2+)Ca(2+)
Transported by ANO9 or HTR3E or TMEM150C or CACNA1A or GRIN2D or P2RX6 or GRID2 or CACNA1G or GRIN3B or CACNA1F or TRPA1 or TRPM2 and 106 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:29671CC BY 4.0Reference data

Other names

3 names

Resolves to: TRPC4

Also called: hTrp-4hTrp4Trp-related protein 4

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