Proteins/UNIPROT:Q6VY07

PACS1

ProteinUNIPROT:Q6VY07

Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity)..

Function from UniProtKB (Q6VY07), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

Schuurs-Hoeijmakers syndrome has a germline basis in PACS1DiseaseGenCC HGNC:30032|MONDO:0014006Inferred only

Statements

29 statements

29 statements · 2 reference databases · Subject: PACS1 · Sources: Hetionet, Reactome

Order

ATP2B3 covaries with PACS1ProteinHetionet hetionet:covaries:492-55690Inferred only
EIF4A3 covaries with PACS1ProteinHetionet hetionet:covaries:55690-9775Inferred only
ERGIC3 covaries with PACS1ProteinHetionet hetionet:covaries:51614-55690Inferred only
MIDN covaries with PACS1ProteinHetionet hetionet:covaries:55690-90007Inferred only
OR2V2 covaries with PACS1ProteinHetionet hetionet:covaries:285659-55690Inferred only
SLC32A1 covaries with PACS1ProteinHetionet hetionet:covaries:140679-55690Inferred only
ZC3H7B covaries with PACS1ProteinHetionet hetionet:covaries:23264-55690Inferred only
PACS1 covaries with ZNF362ProteinHetionet hetionet:covaries:149076-55690Inferred only
AP1G1 interacts with PACS1ProteinHetionet hetionet:interacts:164-55690Inferred only
CLCN7 interacts with PACS1ProteinHetionet hetionet:interacts:1186-55690Inferred only
CSNK2A1 interacts with PACS1ProteinHetionet hetionet:interacts:1457-55690Inferred only
CSNK2B interacts with PACS1ProteinHetionet hetionet:interacts:1460-55690Inferred only

Show the remaining 17

FURIN interacts with PACS1ProteinHetionet hetionet:interacts:5045-55690Inferred only
GGA3 interacts with PACS1ProteinHetionet hetionet:interacts:23163-55690Inferred only
IGF2R interacts with PACS1ProteinHetionet hetionet:interacts:3482-55690Inferred only
JUN interacts with PACS1ProteinHetionet hetionet:interacts:3725-55690Inferred only
PKD2 interacts with PACS1ProteinHetionet hetionet:interacts:5311-55690Inferred only
PPP2CB interacts with PACS1ProteinHetionet hetionet:interacts:5516-55690Inferred only
PACS1 interacts with TRPV4ProteinHetionet hetionet:interacts:55690-59341Inferred only
UBC interacts with PACS1ProteinHetionet hetionet:interacts:55690-7316Inferred only
VAMP4 interacts with PACS1ProteinHetionet hetionet:interacts:55690-8674Inferred only
PACS1 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
PACS1 participates in HIV InfectionPathwayReactome R-HSA-162906Inferred only
PACS1 participates in Host Interactions of HIV factorsPathwayReactome R-HSA-162909Inferred only
PACS1 participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
PACS1 participates in Nef mediated downregulation of MHC class I complex cell surface expressionPathwayReactome R-HSA-164940Inferred only
PACS1 participates in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adaptersPathwayReactome R-HSA-164938Inferred only
PACS1 participates in The role of Nef in HIV-1 replication and disease pathogenesisPathwayReactome R-HSA-164952Inferred only
PACS1 participates in Viral Infection PathwaysPathwayReactome R-HSA-9824446Inferred only

Other names

3 names

Resolves to: PACS1

Also called: KIAA1175PACS-1Phosphofurin acidic cluster sorting protein 1

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