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Proteins/UNIPROT:Q96M94
Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex. Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR)..
Function from UniProtKB (Q96M94), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
17 statements
17 statements · 2 reference databases · Subject: KLHL15 · Sources: gene ontology, Hetionet
2 names
Resolves to: KLHL15